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Effect of Abdominal Sepsis and Different Amino Acid Formulations

Herbert R. Freund, MD; Michael Muggia-Sullam, MD; Richard LaFrance, DPharm; Lois S. Gallon; Uno O. Barcelli, MD; Josef E. Fischer, MD

Arch Surg. 1985;120(9):1037-1038.

Abstract
• Recent in vitro studies attribute regulatory functions to prostaglandins (PGs) in muscle protein metabolism, particularly enhancing proteolysis. In the present study, the amount of muscle PG production from endogenous precursors was determined in control and septic animals (cecal ligation and puncture) that were infused with 5% dextrose or dextrose with three amino acid formulations differing in their branched-chain amino acid (BCAA) content. We could not detect any differences in prostaglandin E, 6-keto-prostaglandin F₁, and thromboxane B₂ production between control and septic animals. Furthermore, the infusion of BCAAs, which have previously been shown to be nitrogen sparing following injury, did not influence the production of any of the PGs studied in either control or septic muscle. It is likely that the effects of the BCAAs on muscle synthesis and degradation are independent of the PGs.

(Arch Surg 1985;120:1037-1039)

Author Affiliations
From the Departments of Surgery (Drs Freund, Muggia-Sullam, LaFrance, and Fischer) and Nephrology (Dr Barcelli and Ms Gallon), University of Cincinnati Medical Center.

Footnotes
Accepted for publication Feb 11, 1985.

Reprint requests to Department of Surgery, University of Cincinnati Medical Center, 231 Bethesda Ave, Cincinnati, OH 45267-0558 (Dr Fischer).

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