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Accurate Measurement by the Delayed-Type Hypersensitivity Skin Test Score

Jean I. Tchervenkov, MD; Esa Diano; Jonathan L. Meakins, MD, FRCSC; Nicolas V. Christou, MD, FRCSC

Arch Surg. 1986;121(1):37-40.

Abstract
• To test the hypothesis that any alteration in the delayed-type hypersensitivity (DTH) skin test response (not necessarily total anergy) reflects increased susceptibility to bacterial sepsis, male Sprague-Dawley rats presensitized to keyholelimpet hemocyanin were subjected to a 30% full-thickness scald burn. Susceptibility to bacteria was assessed by the intradermal injection of Staphylococcus aureus 502A. The DTH response decreased following burn injury from 6.6 to 3.9 mm on days 2 and 8. Skin abscess size increased from 5.8 to 9.3 mm on day 2 and 8.9 mm on day 8. There was a significant inverse correlation between DTH skin test score and abscess size. Histologically there was no difference in the overall leukocyte accumulation in the abscess or the DTH reaction between the two groups, yet the overall size of the abscess was greater and the swelling of the dermis in the DTH response was less in the burned rats.

(Arch Surg 1986;121:37-40)

Author Affiliations
From the Departments of Surgery (Drs Tchervenkov, Meakins, and Christou and Ms Diano) and Microbiology (Drs Meakins and Christou), Royal Victoria Hospital and McGill University, Montreal.

Footnotes
Accepted for publication Oct 1, 1985.

Read before the Fifth Annual Meeting of the Surgical Infection Society, New Orleans, April 29, 1985.

Reprint requests to Royal Victoria Hospital, Room S10.30, 687 Pine Ave W, Montreal, Quebec, Canada H3A 1A1 (Dr Christou).

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