Effect of transfusion on immune function in a traumatized animal model
J. P. Waymack, J. Rapien, D. Garnett, J. S. Tweddell and J. W. Alexander
Blood transfusions repeatedly have been shown to prolong allograft
survival, probably by stimulating suppressor T lymphocytes. The effects of
transfusions on immune function in traumatized patients has not previously
been investigated. We investigated the effects of transfusions on the
immune system using a burned rat model. The transfusions were found to have
no effect on the white blood cell counts, differential cell count, or
neutrophil migration and bactericidal index. Those animals that received
transfusion did exhibit impaired cell-mediated immunity and macrophage
migration. Blood transfusions seem to increase further the
immunosuppression seen with trauma and surgery.
