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Tumoricidal Effects and Patient Survival After Hyperthermic Liver Perfusion
Joseph L. Skibba, MD, PhD;
Edward J. Quebbeman, MD, PhD
Arch Surg. 1986;121(11):1266-1271.
Abstract
• Hyperthermic liver perfusion for four hours at 42.0°C to 42.5°C was used as the sole modality of therapy for cancer confined to the liver in eight patients. Two patients had melanoma, one had cholangiolar carcinoma of the liver, and five had liver metastases from colorectal carcinoma. Two postoperative deaths occurred, both in patients with colorectal carcinoma metastases. Response was indicated by computed tomographic and/or liver biopsy or autopsy findings of tumor necrosis. There were five responders to hyperthermic liver perfusion among the six survivors. Hyperthermic liver perfusion was an effective tumoricidal agent for hepatic metastases from colorectal cancer; ie, tumor necrosis occurred in all five patients, as well as in the two who died, as shown by autopsy findings. Conversion to a disease-free state with hyperthermic perfusion may be possible with other treatment modalities used in combination or sequence.
(Arch Surg 1986;121:1266-1271)
Author Affiliations
From the Medical College of Wisconsin and the Clement J. Zablocki Veterans Administration Medical Center, Milwaukee.
Footnotes
Accepted for publication Aug 14, 1986.
Read before the 39th Annual Meeting of the Society of Surgical Oncology, Washington, DC, May 11, 1986.
Reprint requests to Department of Surgery, Medical College of Wisconsin, 8700 W Wisconsin Ave, Milwaukee, WI 53226 (Dr Skibba).
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