This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Paul L. Baron, MD; Walter Lawrence, Jr, MD; Winnie M. Y. Chan, DrPH; Frances K. H. White; William L. Banks, Jr, PhD

Arch Surg. 1986;121(11):1282-1286.

Abstract
• We attempted to determine whether nutritional supplementation with total parenteral nutrition (TPN) of malnourished patients with untreated squamous cell carcinoma of the head and neck alters tumor growth. Fourteen patients underwent biopsies of normal and malignant tissues and were then placed in either a control or adjuvant TPN group. Nutritional parameters and biopsies were repeated over the ensuing three to 17 days. Biopsy specimens were analyzed by flow cytometry for changes in the percentage of hyperdiploid cells (PHC) and aneuploidy. The PHC of tumor biopsy specimens in patients given TPN increased significantly from 15.1±2.0 to 27.3±3.3, while no such change occurred in normal mucosa. The PHC after TPN was significantly greater in the patients with cancer than that observed in the controls. These data demonstrate that TPN may have a stimulatory effect on tumor cell cycle kinetics in humans.

(Arch Surg 1986;121:1282-1286)

Author Affiliations
From the Division of Surgical Oncology, Department of Surgery (Drs Baron and Lawrence), the Department of Biochemistry (Drs Chan and Banks and Ms White), and the Massey Cancer Center (Drs Lawrence, Chan, and Banks and Ms White), Medical College of Virginia, Virginia Commonwealth University, Richmond.

Footnotes
Accepted for publication Aug 12, 1986.

Read before the 39th Annual Meeting of the Society of Surgical Oncology, Washington, DC, May 13, 1986.

Reprint requests to Division of Surgical Oncology, Box 11, MCV Station, Medical College of Virginia, Richmond, VA 23298 (Dr Lawrence).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Parenteral Nutrition Does Not Stimulate Tumor Proliferation in Malnourished Gastric Cancer Patients
Pacelli et al.
JPEN J Parenter Enteral Nutr 2007;31:451-455.
ABSTRACT | FULL TEXT  

Doing the Right Thing: The Utilization of Evidence-Based Medicine
Koretz
Nutr Clin Pract 2000;15:213-217.
ABSTRACT  

Parenteral vs Enteral Nutrition in Tumor-Bearing Rats
Stallion et al.
JPEN J Parenter Enteral Nutr 1994;18:148-153.
ABSTRACT  

The Effect of an Acute Fast on Human Head and Neck Carcinoma Xenograft: Growth Effects on an 'Isolated Tumor Vascular Pedicle' in the Nude Rat
Goodstein et al.
Arch Otolaryngol Head Neck Surg 1993;119:897-902.
ABSTRACT