This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (82)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Analysis of Presentation, Pathologic Findings, and Outcome of Disease

Marlys E. Schuh, MD; Takuma Nemoto, MD; Remedios B. Penetrante, MD; Dutzu Rosner, MD; Thomas L. Dao, MD

Arch Surg. 1986;121(11):1303-1307.

Abstract
• A retrospective analysis of 52 patients with intraductal carcinoma or ductal carcinoma in situ (DCIS) and 30 patients with microinvasive DCIS was performed. All patients but one were treated by mastectomy. The average follow-up was 5 years. The clinical presentation of the patients having DCIS only included the presence of a mass in 33% (17/52), nipple discharge in 34% (18/52), or suspicious mammographic finding in 33% (17/52), whereas in those patients having DCIS with microinvasion, the initial presenting symptom was a mass in 63% (19/30) of the patients, nipple discharge in 13% (4/30), and mammographic finding in 23% (7/30). The presence of axillary lymph node metastasis was identified in one of the 52 patients with DCIS and six (20%) of the 30 patients with DCIS and microinvasion. Associated carcinomas in the mastectomy specimens of patients with DCIS were as follows: DCIS, 18% (9/51); lobular carcinoma in situ, 13% (7/51); Paget's disease, 8% (4/51); and invasive carcinoma, 2% (1/51). In the 30 patients with microinvasion, DCIS was found in other quadrants in 23% (7/51) of the patients; lobular carcinoma in situ, 7% (2/51); Paget's disease, 13% (4/51); and invasive carcinoma, 7% (2/51). There was one death due to cancer in the patients with DCIS only. Of the patients diagnosed as having DCIS with microinvasion, seven patients have developed metastasis and four have died of the disease.

(Arch Surg 1986;121:1303-1307)

Author Affiliations
From the Departments of Breast Surgery (Drs Schuh, Nemoto, Rosner, and Dao) and Pathology (Dr Penetrante), Roswell Park Memorial Institute, Buffalo.

Footnotes
Accepted for publication Aug 5, 1986.

Read before the 39th Annual Meeting of the Society of Surgical Oncology, Washington, DC, May 13, 1986.

Reprint requests to Department of Breast Surgery, Roswell Park Memorial Institute, 666 Elm St, Buffalo, NY 14263 (Dr Nemoto).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Ductal Carcinoma In Situ, Complexities and Challenges
Leonard and Swain
JNCI J Natl Cancer Inst 2004;96:906-920.
ABSTRACT | FULL TEXT  

Risk Factors for Lymph Node Metastases in Breast Ductal Carcinoma In Situ With Minimal Invasive Component
Wasserberg et al.
Arch Surg 2002;137:1249-1252.
ABSTRACT | FULL TEXT  

Standard for the Management of Ductal Carcinoma In Situ of the Breast (DCIS)
Morrow et al.
CA Cancer J Clin 2002;52:256-276.
ABSTRACT | FULL TEXT  

Age at Diagnosis and Outcome for Women With Ductal Carcinoma-In-Situ of the Breast: A Critical Review of the Literature
Vicini and Recht
JCO 2002;20:2736-2744.
ABSTRACT | FULL TEXT  

Microinvasive Carcinoma of the Breast
Schnitt
INT J SURG PATHOL 1998;6:183-188.
ABSTRACT  

Surgical Treatment of Ductal Carcinoma In Situ of the Breast: 10- to 20-Year Follow-up
Simpson et al.
Arch Surg 1992;127:468-472.
ABSTRACT  

Breast Carcinoma In Situ
Kinne et al.
Arch Surg 1989;124:33-36.
ABSTRACT