Intraductal carcinoma. Analysis of presentation, pathologic findings, and outcome of disease
M. E. Schuh, T. Nemoto, R. B. Penetrante, D. Rosner and T. L. Dao
A retrospective analysis of 52 patients with intraductal carcinoma or
ductal carcinoma in situ (DCIS) and 30 patients with microinvasive DCIS was
performed. All patients but one were treated by mastectomy. The average
follow-up was 5 1/2 years. The clinical presentation of the patients having
DCIS only included the presence of a mass in 33% (17/52), nipple discharge
in 34% (18/52), or suspicious mammographic finding in 33% (17/52), whereas
in those patients having DCIS with microinvasion, the initial presenting
symptom was a mass in 63% (19/30) of the patients, nipple discharge in 13%
(4/30), and mammographic finding in 23% (7/30). The presence of axillary
lymph node metastasis was identified in one of the 52 patients with DCIS
and six (20%) of the 30 patients with DCIS and microinvasion. Associated
carcinomas in the mastectomy specimens of patients with DCIS were as
follows: DCIS, 18% (9/51); lobular carcinoma in situ, 13% (7/51); Paget's
disease, 8% (4/51); and invasive carcinoma, 2% (1/51). In the 30 patients
with microinvasion, DCIS was found in other quadrants in 23% (7/51) of the
patients; lobular carcinoma in situ, 7% (2/51); Paget's disease, 13%
(4/51); and invasive carcinoma, 7% (2/51). There was one death due to
cancer in the patients with DCIS only. Of the patients diagnosed as having
DCIS with microinvasion, seven patients have developed metastasis and four
have died of the disease.
