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The Changing MammogramA Primary Indication for Needle Localization Biopsy
Morton C. Wilhelm, MD;
Ellen S. de Paredes, MD;
Thomas Pope, MD;
Harold J. Wanebo, MD
Arch Surg. 1986;121(11):1311-1314.
Abstract
• Screening mammography results in improved detection and survival for women with breast cancer. Interval mammographic changes may be one of the major indications for biopsy. Four hundred fifty-two needle localization biopsies carried out for microcalcifications, mass, asymmetric density, or a combination of calcifications with mass or asymmetric density detected 95 cancers (21%). Interval mammographic changes detected 35 cases (17.9%). Invasive cancers constituted 51% of the initial group but only 34% of the cancers detected because of interval change. Benign breast disease occurred in 160 of 195 women who had undergone biopsy because of interval changes. These changes continued into the postmenopausal period. Hyperplasia and/or atypia was found in 57 (35%) of 160 of the interval group. Interval mammographic abnormalities detect significant pathologic changes in the breast and should be considered a major indication for breast biopsy.
(Arch Surg 1986;121:1311-1314)
Author Affiliations
From the Division of Surgical Oncology, Department of Surgery (Drs Wilhelm and Wanebo), and the Department of Radiology (Drs de Paredes and Pope), University of Virginia Medical Center, Charlottesville.
Footnotes
Accepted for publication July 31, 1986.
Read before the 39th Annual Meeting of the Society of Surgical Oncology, Washington, DC, May 13, 1986.
Reprint requests to Box 181, Department of Surgery, University of Virginia Medical Center, Charlottesville, VA 22908 (Dr Wilhelm).
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