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Rosemary B. Duda, MD; J. David Beatty, MD; Khalil Sheibani, MD; Lawrence E. Williams, PhD; Raymond J. Paxton, PhD; Barbara G. Beatty, PhD; John E. Shively, PhD; William G. Vlahos; John L. Werner, MD; M. Margaret Kemeny, MD; William A. Kokal, MD; Daniel U. Riihimaki, MD; Lawrence D. Wagman, MD; Jose J. Terz, MD

Arch Surg. 1986;121(11):1315-1319.

Abstract
• Twenty patients with 21 primary colorectal adenocarcinomas were studied with 2 mCi (7.6 x10⁷ becquerels) of indium-labeled monoclonal antibody (200 µg) specific for carcinoembryonic antigen (CEA). Fifteen lesions (71%) were visualized by gamma camera scintigraphy at 48 hours postinjection. Tumors that were identified by immunoscintigraphy were large (38.10±17.76 cm³ vs 6.00±1.65 cm³), had a grossly fungating component, had a high content of CEA by enzyme immunoassay (12.9±3.6 µg/g vs 3.3±1.7 µg/g), and had an apical and/or intraluminal staining pattern on immunohistologic section. Patients whose tumors were visualized had a low serum CEA level (1.9±0.4 ng/mL vs 14.6± 8.0 ng/mL). Prospective selection of patients for follow-up imaging or therapy with radiolabeled monoclonal antibodies may be feasible using these measurements.

(Arch Surg 1986;121:1315-1319)

Author Affiliations
From the Department of General Oncologic Surgery (Drs Duda, J. Beatty, B. Beatty, Kemeny, Kokal, Riihimaki, Wagman, and Terz, and Mr Vlahos), the Divisions of Diagnostic Radiology (Drs Williams and Werner), Immunology (Drs Paxton and Shively), and Anatomic Pathology (Dr Sheibani), the City of Hope National Medical Center, Duarte, Calif.

Footnotes
Accepted for publication July 31, 1986.

Read before the 39th Annual Meeting of the Society of Surgical Oncology, Washington, DC, May 7, 1986.

Reprint requests to Department of General Oncologic Surgery, the City of Hope National Medical Center, 1500 E Duarte Rd, Duarte, CA 91010 (Dr J. Beatty).

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