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Chemoprevention of Colorectal NeoplasmsAscorbic Acid and β-Carotene
Thomas A. Colacchio, MD;
Vincent A. Memoli, MD
Arch Surg. 1986;121(12):1421-1424.
Abstract
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• The organospecific, 1,2-dimethylhydrazine—induced rat tumor model was used to test tumor formation in groups of animals receiving (1) regular chow, (2) powdered chow with 7%/wt ascorbic acid supplement, (3) pelleted chow with 1%/wt β-carotene supplement, and (4) pelleted chow with placebo beadlets. Following a 16-week induction period, animals were killed and tumor formation was recorded. Tumor formation in the ascorbic acid supplement group was found to be significantly less than the control group. The β-carotene group showed no difference in tumor formation compared with the placebo-beadlet control group. Tumor incidence was generally the same between the two control groups, and the ascorbic acid group had significantly fewer tumors than the β-carotene group. In sum, ascorbic acid supplements in high doses significantly decreased tumor formation, whereas β-carotene supplements in moderately high doses had no effect on tumor formation in this model.
(Arch Surg 1986;121:1421-1424)
Author Affiliations
From the Departments of Surgery (Dr Colacchio) and Pathology (Dr Memoli), Dartmouth-Hitchcock Medical Center, Hanover, NH.
Footnotes
Accepted for publication Aug 13, 1986.
Read before the 39th Annual Meeting of the Society of Surgical Oncology, Washington, DC, May 13, 1986.
Reprint requests to Dartmouth-Hitchcock Medical Center, 2 Maynard St, Hanover, NH 03756 (Dr Colacchio).
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ABSTRACT
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