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A Comparison of the Effects of Inspired Oxygen Concentration and Antibiotic Administration on In Vivo Bacterial Clearance

David R. Knighton, MD; Betty Halliday; Thomas K. Hunt, MD

Arch Surg. 1986;121(2):191-195.

Abstract
• Since prophylactic antibiotics and changes in tissue partial pressure of oxygen may affect bacterial clearance by different mechanisms, we tested the effects of hypoxia, hyperoxia, and normoxia with and without antibiotic administration on bacterial clearance. We found that improving tissue oxygenation by administration of normobaric oxygen decreased infectious necrosis as effectively as prophylactic antibiotic administration and that improved tissue oxygenation and antibiotic administration had an additive effect. We believe that a fraction of inspired oxygen of 45% should be added to prophylactic antibiotics as standard perioperative and postoperative care.

(Arch Surg 1986;121:191-195)

Author Affiliations
From the Department of Surgery, University of California at San Francisco. Dr Knighton is now with the Department of Surgery, University of Minnesota, Minneapolis.

Footnotes
Accepted for publication Oct 1, 1985.

Read before the Fifth Annual Meeting of the Surgical Infection Society, New Orleans, April 30, 1985.

Reprint requests to Department of Surgery, University of Minnesota, Box 120 Mayo Hospital, Minneapolis, MN 55455 (Dr Knighton).

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