This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (32)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Second Primary Tumor or Metastasis?

Alan T. Lefor, MD; Carl E. Bredenberg, MD; Robert M. Kellman, MD; John C. Aust, MD

Arch Surg. 1986;121(3):265-270.

Abstract
• Independent primary cancers of the head and neck and of the lung may be confused with lung metastases from a head and neck tumor. We retrospectively reviewed the cases of 55 patients who had head and neck malignancies and pulmonary lesions. To distinguish between independent primary tumors and lung metastases we applied an algorithm using the following criteria: (1) sequence of appearance of the lesions; (2) tumor histology; (3) radiologic appearance of the lesions; and (4) presence of malignant anterior cervical adenopathy. In this group of 55 patients, 40 were categorized as having independent primary malignancies and 15 were categorized as having pulmonary metastases from the head and neck tumor. In cases in which the origin of the pulmonary lesion is unclear, the patient should be treated as though independent primary malignancies were present since this offers the best chance for cure.

(Arch Surg 1986;121:265-270)

Author Affiliations
From the Departments of Surgery (Division of Cardiopulmonary Surgery) (Drs Lefor and Bredenberg) and Otolaryngology (Dr Kellman), State University of New York (SUNY) Upstate Medical Center, Syracuse, and Syracuse Veterans Administration Medical Center (Dr Aust).

Footnotes
Accepted for publication Sept 26, 1985.

Read before the Ninth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Tampa, Fla, May 10, 1985.

Reprint requests to Department of Surgery, SUNY Upstate Medical Center, Syracuse, NY 13210 (Dr Bredenberg).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pulmonary Squamous Cell Carcinoma following Head and Neck Squamous Cell Carcinoma: Metastasis or Second Primary?
Geurts et al.
Clin. Cancer Res. 2005;11:6608-6614.
ABSTRACT | FULL TEXT  

A Randomized Trial of Antioxidant Vitamins to Prevent Second Primary Cancers in Head and Neck Cancer Patients
Bairati et al.
JNCI J Natl Cancer Inst 2005;97:481-488.
ABSTRACT | FULL TEXT  

Relationship Between a History of Antecedent Cancer and the Probability of Malignancy for a Solitary Pulmonary Nodule
Mery et al.
Chest 2004;125:2175-2181.
ABSTRACT | FULL TEXT  

Positron Emission Tomography in the Evaluation of Synchronous Lung Lesions in Patients With Untreated Head and Neck Cancer
Wax et al.
Arch Otolaryngol Head Neck Surg 2002;128:703-707.
ABSTRACT | FULL TEXT  

Solitary Pulmonary Nodules in Patients with Extrapulmonary Neoplasms
Quint et al.
Radiology 2000;217:257-261.
ABSTRACT | FULL TEXT  

COMBINED THORACOSCOPIC/LAPAROSCOPIC STAGING OF ESOPHAGEAL CANCER
Krasna et al.
J. Thorac. Cardiovasc. Surg. 1996;111:800-807.
ABSTRACT | FULL TEXT  

Toluidine Blue Staining of the Esophagus: A Useful Adjunct in the Panendoscopic Evaluation of Patients With Squamous Cell Carcinoma of the Head and Neck
Hix and Wilson
Arch Otolaryngol Head Neck Surg 1987;113:864-865.
ABSTRACT