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Mary Pat Moyer, PhD; Anna Armstrong, MD; J. Bradley Aust, MD, PhD; Barry A. Levine, MD; Kenneth R. Sirinek, MD, PhD

Arch Surg. 1986;121(3):285-288.

Abstract
• This study evaluated the dose-related trophic effects of glutamine, gastrin, and somatostatin on the in vitro growth of human gastric cancer cells and normal human gastric mucosal cells. Quadruplicate cell cultures were seeded into growth medium with or without glutamine, gastrin, or somatostatin. After 72 hours' incubation, cells were counted and their numbers compared with those of controls. Glutamine and gastrin stimulated the growth of both normal and malignant gastric mucosal cells. Compared with normal cells, the malignant cells responded to these growth factors at lower concentrations. Somatostatin enhanced growth of gastric cancer cells at all concentrations and inhibited growth of normal cells at high concentrations. Further studies on the responsiveness of gastric adenocarcinoma to gastrointestinal tract hormones may elucidate mechanisms of oncogenesis and suggest new therapeutic avenues for patients with gastric cancer.

(Arch Surg 1986;121:285-288)

Author Affiliations
From the Department of Surgery, The University of Texas Health Science Center and the Audie L. Murphy Memorial Veterans Hospital, San Antonio, Tex.

Footnotes
Accepted for publication Sept 26, 1985.

Read before the Ninth Annual Meeting of the Association of Veterans Administration Surgeons, Tampa, Fla, May 10, 1985.

Reprint requests to Department of Surgery, The University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78284 (Dr Moyer).

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