 |
|
|
Vol. 121 No. 3, March 1986 |
 |
|
|
|
|
|
|
|
|
|
PAPERS READ BEFORE THE NINTH ANNUAL SURGICAL SYMPOSIUM OF THE ASSOCIATION OF VETERANS ADMINISTRATION SURGEONS, TAMPA, FLA, MAY 8-11, 1985 |
|
|
|
β-Adrenergic Blockade Increases the Hepatic Extraction of Glucose in Sepsis
Joseph A. Caruana, MD;
Daniel A. Whalen, Jr, MD;
Wayne C. Maben, MD;
Hao-Hui Chen, MD
Arch Surg. 1986;121(3):319-323.
Abstract
| |
• To determine the relationship between hepatic glucose clearance and elevated epinephrine levels in sepsis, dogs with gangrenous cholecystitis were anesthetized and received either propranolol hydrochloride (mean dose, 0.29 mg/kg) or saline solution before intraduodenal glucose injection (2.5 g/kg). The amounts of glucose, insulin, and glucagon in the portal vein, the hepatic artery, and the hepatic vein were determined from the concentrations and the blood flows in these vessels over a two-hour period. Normal dogs served as controls. The amounts of glucose, insulin, and glucagon reaching the livers of both septic groups were the same. However, propranolol treatment increased the percent of glucose extracted by the liver without affecting the extractions of insulin or glucagon. Propranolol reverses the limitation of hepatic glucose extraction in sepsis by a direct effect. Whether the extracted glucose is utilizable as an energy substrate needs to be established.
(Arch Surg 1986;121:319-323)
Author Affiliations
From the Departments of Surgery (Drs Caruana, Maben, and Chen) and Anesthesiology (Dr Whalen), State University of New York at Buffalo; and the Veterans Administration Medical Center, Buffalo.
Footnotes
Accepted for publication Dec 2, 1985.
Read before the Ninth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Tampa, Fla, May 11, 1985.
Reprint requests to Veterans Administration Medical Center, 3495 Bailey Ave, Buffalo, NY 14215 (Dr Caruana).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
|
|
