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Response to Ischemia and Reperfusion

Eric S. Weinstein, MD; Michael L. Spector, MD; E. Merrill Adams, PhD; Michael D. Yokum; Rachel W. Humphrey; Donald E. Fry, MD

Arch Surg. 1986;121(3):324-329.

Abstract
• The relationships between cardiac bioenergy metabolism and myocardial function were examined in a model of global myocardial ischemia and reperfusion. The respiratory activity of distinct populations of subsarcolemmal and interfibrillar mitochondria was correlated with max dP/dt (an index of myocardial contractility with respect to time). Max dP/dt was significantly reduced to 27% of the preischemic value following two hours of cardioplegia-protected, warm, global, ischemia in dogs during the cardiopulmonary bypass period. Reperfusion resulted in improved myocardial function such that by 60 minutes of reperfusion, max dP/dt returned to baseline. Significant declines in both state 3 respiratory rates and respiratory control indexes for subsarcolemmal and interfibrillar mitochondria were noted following the ischemic interval. Mitochondrial function similarly returned to baseline values following 60 minutes of reperfusion. These data demonstrate a close association between mitochondrial and myocardial activity.

(Arch Surg 1986;121:324-329)

Author Affiliations
From the Departments of Surgery (Drs Weinstein and Fry and Mr Yokum) and Cardiothoracic Surgery (Drs Spector and Adams and Ms Humphrey), Case Western Reserve University School of Medicine, and the Veterans Administration Medical Center (Drs Weinstein and Fry and Mr Yokum), Cleveland. Dr Weinstein is a Dudley P. Allen Research Fellow for the Department of Surgery, Case Western Reserve University School of Medicine.

Footnotes
Accepted for publication Sept 26, 1985.

Read before the Ninth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Tampa, Fla, May 10, 1985.

Reprint requests to Surgical Service (112W), Veterans Administration Medical Center, 10701 East Blvd, Cleveland, OH 44106 (Dr Fry).

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