You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 121 No. 3, March 1986 TABLE OF CONTENTS
  Archives
  •  Online Features
  PAPERS READ BEFORE THE NINTH ANNUAL SURGICAL SYMPOSIUM OF THE ASSOCIATION OF VETERANS ADMINISTRATION SURGEONS, TAMPA, FLA, MAY 8-11, 1985
 This Article
 •References
 •Full text PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (5)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Mitochondrial and Myocardial Performance

Response to Ischemia and Reperfusion

Eric S. Weinstein, MD; Michael L. Spector, MD; E. Merrill Adams, PhD; Michael D. Yokum; Rachel W. Humphrey; Donald E. Fry, MD

Arch Surg. 1986;121(3):324-329.


Abstract

• The relationships between cardiac bioenergy metabolism and myocardial function were examined in a model of global myocardial ischemia and reperfusion. The respiratory activity of distinct populations of subsarcolemmal and interfibrillar mitochondria was correlated with max dP/dt (an index of myocardial contractility with respect to time). Max dP/dt was significantly reduced to 27% of the preischemic value following two hours of cardioplegia-protected, warm, global, ischemia in dogs during the cardiopulmonary bypass period. Reperfusion resulted in improved myocardial function such that by 60 minutes of reperfusion, max dP/dt returned to baseline. Significant declines in both state 3 respiratory rates and respiratory control indexes for subsarcolemmal and interfibrillar mitochondria were noted following the ischemic interval. Mitochondrial function similarly returned to baseline values following 60 minutes of reperfusion. These data demonstrate a close association between mitochondrial and myocardial activity.

(Arch Surg 1986;121:324-329)



Author Affiliations

From the Departments of Surgery (Drs Weinstein and Fry and Mr Yokum) and Cardiothoracic Surgery (Drs Spector and Adams and Ms Humphrey), Case Western Reserve University School of Medicine, and the Veterans Administration Medical Center (Drs Weinstein and Fry and Mr Yokum), Cleveland. Dr Weinstein is a Dudley P. Allen Research Fellow for the Department of Surgery, Case Western Reserve University School of Medicine.


Footnotes

Accepted for publication Sept 26, 1985.

Read before the Ninth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Tampa, Fla, May 10, 1985.

Reprint requests to Surgical Service (112W), Veterans Administration Medical Center, 10701 East Blvd, Cleveland, OH 44106 (Dr Fry).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

METABOLIC AND HEMODYNAMIC EFFECTS OF INTRAVENOUS GLUTAMATE INFUSION EARLY AFTER CORONARY OPERATIONS
Svedjeholm et al.
J. Thorac. Cardiovasc. Surg. 1996;112:1468-1477.
ABSTRACT | FULL TEXT  

Direct and Interactive Effects of Cardioplegic Arrest and Protamine on Myocyte Contractility
O et al.
Ann. Thorac. Surg. 1996;62:489-494.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1986 American Medical Association. All Rights Reserved.