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Debra A. Goller, MD; Wibo F. Weidema, MD; Richard J. Davies, MD

Arch Surg. 1986;121(3):345-350.

Abstract
• It has been suggested that relative depolarization of the cell membrane occurs during carcinogenesis. A study was undertaken to determine the effect on the colonic transmural potential difference in CF₁ mice following the administration of a carcinogen, a cytotoxic agent, and bile acids. Depolarization of the distal colonic mucosa was seen in mice treated with the carcinogen but not with the cytotoxic agent, and bile acids caused further depolarization of the mucosa. These experiments support the hypothesis that epithelial depolarization is a putative mechanism in carcinogenesis, which could have important implications for the early detection of colon cancer.

(Arch Surg 1986;121:345-350)

Author Affiliations
From the Departments of Surgery, Veterans Administration Medical Center, San Diego, and the University of California, San Diego Medical Center.

Footnotes
Accepted for publication Oct 3, 1985.

Read before the Ninth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Tampa, Fla, May 10, 1985.

Reprint requests to Surgical Service, VA Medical Center, 3350 La Jolla Village Dr, San Diego, CA 92161 (Dr Davies).

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