This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (3)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Charles E. Lucas, MD; Donald J. Martin, MD; Anna M. Ledgerwood, MD; Judy Hoschner, MD; Michael D. McGonigal, MD; Karl Kithier, MD; Vishwanath M. Sardesai, MD

Arch Surg. 1986;121(5):559-564.

Abstract
• The adverse effects of albumin resuscitation on coagulation activity, cardiopulmonary function, and extravascular flux of nonalbumin protein have made fresh-frozen plasma (FFP) an attractive alternate volume expander for hemorrhagic shock. This study addresses the effects of FFP on cardiopulmonary hemodynamics and protein flux. Whole blood was collected three and six weeks before shock, separated into red blood cells (PRBCs) and FFP, and stored. In 24 conditioned splenectomized dogs, resuscitation from reservoir shock of two hours' duration consisted of autologous PRBCs and balanced electrolyte solution (BES) in control dogs and PRBCs, BES, and FFP in plasma-treated dogs. Hemorrhagic shock reduced serum albumin and IgG levels in both groups. Resuscitation with FFP led to a higher cardiac output, left ventricular stroke work (LVSW), and pulmonary capillary wedge pressure (PCWP). The PCWP/LVSW ratio was comparable for both groups. Postshock day 2 serum albumin and IgG levels and lymphatic albumin and IgG concentrations were increased in plasma dogs. Therefore, FFP supplement to PRBC and BES resuscitation does not derange the PCWP/LVSW ratio or reduce intravascular nonalbumin proteins.

(Arch Surg 1986;121:559-564)

Author Affiliations
From the Departments of Surgery (Drs Lucas, Martin, Ledgerwood, McGonigal, and Sardesai) and Pathology (Drs Hoschner and Kithier), Wayne State University, Detroit.

Footnotes
Accepted for publication Jan 28, 1986.

Read before the 93rd annual meeting of the Western Surgical Association, Rochester, Minn, Nov 19, 1985.

Reprint requests to Department of Surgery, Wayne State University, 4201 St Antoine, Detroit, MI 48201 (Dr Lucas).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Hypertonic saline-dextran suppresses burn-related cytokine secretion by cardiomyocytes
Horton et al.
Am. J. Physiol. Heart Circ. Physiol. 2001;280:H1591-H1601.
ABSTRACT | FULL TEXT