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Robert F. Wilson, MD; Eberhard F. Mammen, MD; Martin C. Robson, MD; John P. Heggers, PhD; George Soullier; Patricia A. DePoli

Arch Surg. 1986;121(6):635-640.

Abstract
• Antithrombin (AT), prekallikrein (PK), and fibronectin (FN) levels were measured in the plasma of 290 patients. The mean (± SD) lowest AT level measured in 287 patients was 70% ± 18% (normal, 75% to 120% of control). The mean lowest AT level in 81 septic patients (49% ± 17%) was significantly lower than in the 206 patients without sepsis (78% ± 22%). The mean AT level in 60 patients who died (42% ± 22%) was significantly lower than in 227 patients who lived (78% ± 19%). The mean lowest PK level measured in 71 patients was 42% ± 17% (normal, 80% to 120%). The mean PK level in 32 septic patients (26% ± 12%) was significantly lower than in 39 patients who were not septic (54% ± 19%). The mean lowest FN level measured in 45 patients was 193 ± 86 µg/mL (normal, 160 to 240 µg/mL). The mean FN level in 15 septic patients (128 ± 72 µg/mL) was significantly lower than in the 30 nonseptic patients (266± 84 µg/mL). Following AT, PK, and FN levels in critically ill surgical patients may allow earlier diagnosis and more effective treatment of sepsis.

(Arch Surg 1986;121:635-640)

Author Affiliations
From the Department of Surgery (Dr Wilson and Mr Soullier) and the Burn Center (Drs Robson and Heggers), Detroit Receiving Hospital—University Health Center, and the Department of Pathology and Physiology, Wayne State University School of Medicine, Detroit (Dr Mammen and Ms DePoli).

Footnotes
Accepted for publication May 4, 1986.

Read before the 93rd Annual Meeting of the Western Surgical Association, Rochester, Minn, Nov 20, 1985.

Reprint requests to Wayne State University, Department of Surgery, 6-C University Health Center, 4201 St Antoine, Detroit, MI 48201 (Dr Wilson).

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