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Jeffrey Innes, MD; Ian Fraser, MD; Larry C. Carey, MD

Arch Surg. 1986;121(6):665-668.

Abstract
• The hemodynamic effect of pancreatic ascitic fluid was studied in a porcine model. Pancreatitis was induced by a low-pressure infusion of trypsin and taurocholate sodium into the pancreatic duct. The ascitic fluid that accumulated was then injected into the inferior vena cava of five pigs, with each pig receiving five infusions at 40-minute intervals. Mean arterial blood pressure and peripheral vascular resistance fell with each infusion, while pulmonary artery pressure increased. The magnitude of the drop in arterial blood pressure decreased with subsequent infusions, suggesting tachyphylaxis. The rise in pulmonary artery pressure increased with successive infusions. Anesthesia artifact and decay of the pancreatic ascitic fluid were ruled out as causes of the tachyphylaxis. Filtration separated the substances producing pulmonary effects and systemic blood pressure effects (0.2 to 11 µm vs 10,000 daltons to 0.2 µm). These data suggest that two mediators may produce the hemodynamic effects of pancreatic ascitic fluid.

(Arch Surg 1986;121:665-668)

Author Affiliations
From the Department of Surgery, The Ohio State University College of Medicine, Columbus.

Footnotes
Accepted for publication Dec 30, 1985.

Read before the 93rd Annual Meeting of the Western Surgical Association, Rochester, Minn, Nov 20, 1985.

Reprint requests to Department of Surgery, The Ohio State University College of Medicine, 410 W Tenth Ave, Columbus, OH 43210 (Dr Innes).

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