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Antiplatelet Therapy and Vascular GraftsStudies in a Baboon Ex Vivo Shunt
Jens Eldrup-Jorgensen, MD;
Raymond J. Connolly, PhD;
William C. Mackey, MD;
Karen Ramberg, MS;
Thomas F. O'Donnell, MD;
C. Robert Valeri, MD;
Allan D. Callow, MD, PhD
Arch Surg. 1986;121(7):778-781.
Abstract
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• Antiplatelet therapy is currently recommended in an effort to improve patency rates of small-caliber vascular grafts. The effect of aspirin and heparin on acute platelet deposition was studied in a baboon ex vivo shunt. Two grafts, expanded polytetrafluoroethylene and knitted Dacron, were exposed to a flow rate of 25 mL/min after administration of aspirin or heparin. Indium 111–labeled platelet uptake by the grafts was determined over 2 hours. The amount of platelet deposition in the treated groups was significantly less than that of controls after 2 hours. There was no difference between the aspirin and heparin groups. The finding that heparin inhibited platelet deposition to a degree comparable with aspirin suggests that it may not be necessary to start antiplatelet therapy preoperatively. Intraoperative systemic heparinization will provide sufficient inhibition of platelet deposition. A protocol for perioperative antiplatelet therapy is outlined.
(Arch Surg 1986;121:778-781)
Author Affiliations
From the Departments of Surgery (Drs Eldrup-Jorgensen, Connolly, Mackey, O'Donnell, and Callow) and Radiology (Ms Ramberg), Tufts University School of Medicine and the New England Medical Center, Boston; and the Naval Blood Research Laboratory, Boston University School of Medicine (Dr Valeri).
Footnotes
Accepted for publication Dec 4, 1985.
Read before the 12th Annual Meeting of the New England Society for Vascular Surgery, Whitefield, NH, Oct 11, 1985.
Reprint requests to Box 285, Tufts—New England Medical Center, 171 Harrison Ave, Boston, MA 02111 (Dr Callow).
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