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A Randomized Trial in 50 Patients

Edgar Borrero, MD; Joy Ciervo, RN; John B. Chang, MD

Arch Surg. 1986;121(7):810-812.

Abstract
• We carried out a randomized, controlled trial of sucralfate vs antacid as prophylaxis against upper gastrointestinal tract bleeding in 50 patients who had undergone abdominal aortic surgery. The groups were similar in age, sex, duration of prophylaxis, and number of risk factors per patient. No patient in the antacid group had upper gastrointestinal tract bleeding. One patient in the sucralfate group had frank bleeding from the nasogastric tube; however, she also had a coagulopathy and thrombocytopenia. The bleeding stopped when these conditions were corrected. No complications occurred in the sucralfate group; five patients in the antacid group had minor complications. Sucralfate was as effective as antacid in this trial, and it resulted in a considerable saving in nursing time.

(Arch Surg 1986;121:810-812)

Author Affiliations
From the Division of Vascular Surgery, Department of Surgery (Drs Borrero and Chang), and the Intensive Care Unit (Ms Ciervo), Long Island Jewish Medical Center, New Hyde Park, NY; and State University of New York at Stony Brook (Drs Borrero and Chang).

Footnotes
Accepted for publication Oct 8, 1985.

Reprint requests to Division of Vascular Surgery, Long Island Jewish Medical Center, New Hyde Park, NY 11042 (Dr Chang).

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