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An Experimental Model

R. Jan A. Goris, MD; Willem K. F. Boekholtz, MD; Ignas P. T. van Bebber, MD; Johan K. S. Nuytinck, MD; Paul H. M. Schillings, MD

Arch Surg. 1986;121(8):897-901.

Abstract
• Multiple-organ failure is generally attributed to bacterial infection, although a correlation with positive blood cultures is not consistently found. Consequently, we studied the effects of a local nonbacterial inflammatory stimulus on distant organ functions and metabolism. Wistar rats were inoculated intraperitoneally with zymosan. Heart and ventilatory rates, oxygen consumption, and body temperature were measured. Survivors were killed at day 12 for blood analysis, weighing of organs, and microscopy. Intraperitoneal zymosan resulted in an early hyperdynamic "septic" response with a 35% mortality. After a few days, oxygen consumption decreased, serum lactate levels increased, and the function of multiple organs deteriorated, while blood cultures remained sterile. The experiment was repeated in germ-free rats with similar results but a lower mortality. We concluded that a severe inflammatory response in itself is capable of inducing multiple-organ failure with "sepsis."

(Arch Surg 1986;121:897-901)

Author Affiliations
From the Departments of General Surgery (Drs Goris, Boekholtz, van Bebber, and Nuytinck) and Pathologic Anatomy (Dr Schillings), University Hospital St Radboud, Nijmegen, the Netherlands.

Footnotes
Accepted for publication Dec 2, 1985.

Reprint requests to Department of General Surgery, University Hospital St Radboud, PO Box 9101, 6500 HB Nijmegen, the Netherlands (Dr Goris).

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