This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Its Association With Posttraumatic Complications and Its Reversal With Immunomodulation

Eugen Faist, MD; Thomas S. Kupper, MD; Christopher C. Baker, MD; Irshaud H. Chaudry, PhD; John Dwyer, MD, PhD; Arthur E. Baue, MD

Arch Surg. 1986;121(9):1000-1005.

Abstract
• This study examined a group of surgical patients with respect to the ability of their peripheral blood mononuclear cells to respond to phytohemagglutinin (PHA). Depression of the PHA response of more than 30% below baseline five to seven days after injury was found in 11 of 19 patients, and eight of them developed infectious complications. The addition of indomethacin to in vitro cultures resulted in an average enhancement of the PHA response of 37% baseline. Improvement at five to seven days with in vitro indomethacin was from 34% to 74% in infected patients. These data suggest that major injury can lead to depression of the PHA response, which correlates with the subsequent development of infectious complications. Indomethacin in vitro seems to be able to reverse or decrease this immunologic defect and deserves further study.

(Arch Surg 1986;121:1000-1005)

Author Affiliations
From the Department of Surgery, Grosshadern Clinic, Munich (Dr Faist); the Department of Surgery, Yale University School of Medicine, New Haven (Drs Kupper, Baker, Chaudry, and Baue); and the Department of Medicine, Prince of Wales Hospital, Rendwick, New South Wales, Australia (Dr Dwyer).

Footnotes
Accepted for publication March 18, 1986.

Read before the papers session of the Clinical Congress of the American College of Surgeons, San Francisco, Oct 22, 1984.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Regulatory T cell populations in sepsis and trauma
Venet et al.
J. Leukoc. Biol. 2008;83:523-535.
ABSTRACT | FULL TEXT  

A case for immunization against nosocomial infections
Cross et al.
J. Leukoc. Biol. 2008;83:483-488.
ABSTRACT | FULL TEXT  

Burn Wound Infections
Church et al.
Clin. Microbiol. Rev. 2006;19:403-434.
ABSTRACT | FULL TEXT  

Corticosterone binding globulin regulation and thymus changes after thermal injury in mice
D'Elia et al.
Am. J. Physiol. Endocrinol. Metab. 2005;288:E852-E860.
ABSTRACT | FULL TEXT  

CD4+CD25+ Regulatory T Cells Control Innate Immune Reactivity after Injury
Murphy et al.
J. Immunol. 2005;174:2957-2963.
ABSTRACT | FULL TEXT  

Bacterial Clearance and Cytokine Profiles in a Murine Model of Postsurgical Nosocomial Pneumonia
Manderscheid et al.
CVI 2004;11:742-751.
ABSTRACT | FULL TEXT  

Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappa B and MAPK/ERK mechanisms
Jarrar et al.
Am. J. Physiol. Lung Cell. Mol. Physiol. 2002;283:L799-L805.
ABSTRACT | FULL TEXT  

Protective Effects of Early Interleukin 10 Antagonism on Injury-Induced Immune Dysfunction
Lyons et al.
Arch Surg 1999;134:1317-1324.
ABSTRACT | FULL TEXT  

Therapeutic Protective Effects of IL-12 Combined with Soluble IL-4 Receptor Against Established Infections of Herpes Simplex Virus Type 1 in Thermally Injured Mice
Kobayashi et al.
J. Immunol. 1999;162:7148-7154.
ABSTRACT | FULL TEXT  

Interleukin-10: A Role in the Development of Postoperative Immunosuppression
Klava et al.
Arch Surg 1997;132:425-429.
ABSTRACT  

Immune Function Is More Compromised After Closed Bone Fracture and Hemorrhagic Shock Than Hemorrhage Alone
Wichmann et al.
Arch Surg 1996;131:995-1000.
ABSTRACT  

Physiological classification and stratification of illness severity of posttrauma 'sepsis' patients as a basis for randomization of clinical trials
Siegel et al.
Innate Immunity 1995;2:177-188.
 

Administration of Dehydroepiandrosterone to Burned Mice Preserves Normal Immunologic Competence
Araneo et al.
Arch Surg 1993;128:318-325.
ABSTRACT  

Anergy in Pediatric Head Trauma Patients
Wilson et al.
Arch Pediatr Adolesc Med 1991;145:326-329.
ABSTRACT  

The Effect of High Lipid Diet on In Vitro Prostaglandin E2 and Thromboxane B2 Production by Splenic Macrophages
Ogle et al.
JPEN J Parenter Enteral Nutr 1990;14:250-254.
ABSTRACT  

The Immune-Enhancing Effect of Perioperative Thymopentin Administration in Elderly Patients Undergoing Major Surgery
Faist et al.
Arch Surg 1988;123:1449-1453.
ABSTRACT  

Alteration of Monocyte Function Following Major Injury
Faist et al.
Arch Surg 1988;123:287-292.
ABSTRACT  

Lymphocyte Function and Abdominal Operations: Trauma vs Elective Surgery
Feliciano et al.
Arch Surg 1987;122:697-701.
ABSTRACT