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Tommy Skau, MD, PhD; Per-Olof Nyström, MD, PhD; Lena Ohman, MD, PhD; Olle Stendahl, MD, PhD

Arch Surg. 1986;121(9):1033-1039.

Abstract
• In a study using pigs, we delineated the dynamic character and the interplay of defense mechanisms that operate in the peritoneal cavity and their effectiveness against Escherichia coli and Bacteroides fragilis. The bacteria were extensively cleared during the first three hours. The concentration of both organisms in the peritoneal fluid decreased by up to 300 000-fold, and the final concentration was a function of the inoculum given. Clearance efficiency did not differ between a bolus dose and prolonged bacterial administration. Peritoneal absorption was a major eliminating mechanism during the first three hours but was limited to bacterial concentrations exceeding approximately 10⁹ colony-forming units per milliliter of peritoneal fluid. Intraperitoneal elimination started immediately and continued for approximately six hours. Thereafter, residual bacteria were not eliminated, even though the defense capacity was intact. Prolonged bacterial administration, however, protracted the period for active bacterial destruction.

(Arch Surg 1986;121:1033-1039)

Author Affiliations
From the Departments of Surgery (Drs Skau and Nyström) and Medical Microbiology (Drs Öhman and Stendahl), University Hospital, Linköping, Sweden.

Footnotes
Accepted for publication March 6, 1986.

Reprint requests to the Department of Surgery, University Hospital, S-581 85 Linköping, Sweden (Dr Skau).

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