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Macrophages and Translymphatic Absorption Represent the First Line of Host Defense of the Peritoneal Cavity
David L. Dunn, MD, PhD;
Roderick A. Barke, MD;
David C. Ewald;
Richard L. Simmons, MD
Arch Surg. 1987;122(1):105-110.
Abstract
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• To quantitate the host defenses of the rat peritoneal cavity, nonviable radiolabeled Escherichia coli were injected intraperitoneally and clearance, leukocyte influx, and phagocytosis were examined. Macrophages (MCs) were present initially and remained relatively constant in number. The polymorphonuclear leukocyte (PMN) response began at one to two hours and was maximal at 24 to 72 hours. A previously unidentified inoculum-dependent PMN response was defined. Clearance and phagocytosis were extremely rapid, and few (<3%) free bacteria were present after two hours. Phagocytic activity of MCs and PMNs was identical, but MCs were numerically predominant initially and thus accounted for the majority of early phagocytosis. Thus, MC phagocytosis and clearance represent the primary line of host peritoneal defenses. We hypothesize that the subsequent inoculum-dependent PMN response may have evolved to cope with those larger inocula for which this initial response is inadequate.
(Arch Surg 1987;122:105-110)
Author Affiliations
From the Department of Surgery, University of Minnesota, Minneapolis.
Footnotes
Accepted for publication Aug 14, 1986.
Read before the Sixth Annual Meeting of the Surgical Infection Society, Chicago, April 21, 1986.
Reprint requests to Box 242 Mayo Memorial Bldg, 420 Delaware St SE, University of Minnesota, Minneapolis, MN 55455 (Dr Dunn).
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