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III. Alterations in Macrophage Arachidonic Acid Metabolism

J. Paul Waymack, MD; Lois Gallon; Uno Barcelli, MD; Orrawin Trocki, MS, RD; J. Wesley Alexander, MD, ScD

Arch Surg. 1987;122(1):56-60.

Abstract
• Blood transfusions have been shown to prevent allograft rejection, to increase the rate of tumor growth, and to increase susceptibility to infectious complications. We evaluated the mechanism of this immunosuppression by studying the effect of transfusions on macrophage function in a Lewis rat model. Allogeneic transfusions were found to decrease macrophage migration in response to inflammatory stimuli and to increase their production of the strongly immunosuppressive arachidonic acid metabolite prostaglandin E. Syngeneic transfusions did not alter macrophage migration or arachidonic acid metabolism. The immunosuppression seen following transfusions appears to be related to an increased synthesis of prostaglandin E.

(Arch Surg 1987;122:56-60)

Author Affiliations
From the Shriners Burns Institute, Cincinnati (Drs Waymack and Alexander and Mr Trocki), and University of Cincinnati College of Medicine (Drs Waymack, Barcelli, and Alexander and Ms Gallon).

Footnotes
Accepted for publication Sept 4, 1986.

Read before the Sixth Annual Meeting of the Surgical Infection Society, Chicago, April 21, 1986.

Reprint requests to Shriners Burns Institute, 202 Goodman St, Cincinnati, OH 45219 (Dr Waymack).

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