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Supplemental Dietary Tyrosine in Sepsis and Acute Hemorrhagic Shock
Ronald Simon, MD;
Warren Wetzel, MD;
Kim Winsey, MD;
Stanley M. Levenson, MD;
Achilles A. Demetriou, MD, PhD
Arch Surg. 1987;122(1):78-81.
Abstract
• Previous studies showed that dopamine and norepinephrine levels in rat brain are reduced following stress and that rats fed supplemental tyrosine do not exhibit these reductions. We hypothesized that dietary supplementation with tyrosine would enhance resistance to acute hemorrhagic shock and sepsis by increasing substrate (tyrosine) availability for catecholamine synthesis. Rats were fed either a standard rat chow (6.8 g of tyrosine per kilogram of chow), which supports normal growth, fertility, and longevity, or the same chow supplemented with 10 g of tyrosine per kilogram of chow. Seven days later, the rats underwent cecal ligation and perforation while under intraperitoneal pentobarbital anesthesia. There was a significant increase in survival in the tyrosinesupplemented group. Similarly, in another experiment, tyrosine-supplemented rats were able to tolerate acute fulminant hemorrhagic shock better than were nonsupplemented control animals.
(Arch Surg 1987;122:78-81)
Author Affiliations
From the Combined Departments of Surgery, Albert Einstein College of Medicine, Yeshiva University, and Montefiore Medical Center, Bronx, NY.
Footnotes
Accepted for publication July 22, 1986.
Read before the Sixth Annual Meeting of the Surgical Infection Society, Chicago, April 21, 1986.
Reprint requests to Department of Surgery, Vanderbilt University Medical Center, T-2119 MCN, Nashville, TN 37232 (Dr Demetriou).
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