This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Henry M. Cryer, MD; R. Neal Garrison, MD; Herman W. Kaebnick, MD; Patrick D. Harris, PhD; Lewis M. Flint, MD

Arch Surg. 1987;122(1):86-92.

Abstract
• To determine the microvascular site of vasodilation during hyperdynamic sepsis, we measured arteriolar and venular responses to live Escherichia coli bacteremia in the rat cremaster muscle by direct in vivo videomicroscopy. Our data indicate that cardiac output (by thermodilution) increased, systemic vascular resistance decreased, and a differential arteriolar response occurred, with constriction of large arterioles and dilation of small terminal arterioles. We conclude that dilation of small terminal arterioles in skeletal muscle could contribute to decreased systemic vascular resistance during hyperdynamic sepsis. This may be an appropriate response to increased oxygen demand or decreased tissue utilization of oxygen. Alternatively, small-arteriole dilation may be an inappropriate response and secondary to release of vasoactive inflammatory mediators. If the latter is true, there is a potential therapeutic role for selective manipulation of the tone of small terminal arterioles in hyperdynamic sepsis.

(Arch Surg 1987;122:86-92)

Author Affiliations
From the Departments of Surgery (Drs Cryer, Garrison, Kaebnick, and Flint) and Physiology and Biophysics (Dr Harris), University of Louisville (Ky) School of Medicine.

Footnotes
Accepted for publication Sept 10, 1986.

Read before the Sixth Annual Meeting of the Surgical Infection Society, Chicago, April 22, 1986.

Reprint requests to Department of Surgery, University of Louisville, 550 S Jackson, Louisville, KY 40292 (Dr Cryer).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Microvascular Blood Flow Is Altered in Patients with Sepsis
De Backer et al.
Am. J. Respir. Crit. Care Med. 2002;166:98-104.
ABSTRACT | FULL TEXT  

Effect of a maldistribution of microvascular blood flow on capillary O2 extraction in sepsis
Ellis et al.
Am. J. Physiol. Heart Circ. Physiol. 2002;282:H156-H164.
ABSTRACT | FULL TEXT  

Effects of Pseudomonas aeruginosa endotoxin on vasodilation in the intact spinotrapezius muscle
Suzuki et al.
J. Appl. Physiol. 2001;91:351-356.
ABSTRACT | FULL TEXT  

Mast Cell Chymase-Like Protease(s) Modulates Escherichia coli Lipopolysaccharide-Induced Vasomotor Dysfunction in Skeletal Muscle in Vivo
Suzuki et al.
J. Pharmacol. Exp. Ther. 1998;284:1156-1164.
ABSTRACT | FULL TEXT