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A New Diagnostic Parameter

Constantine P. Karakousis, MD, PhD; Paola Dal Cin, PhD; Claude Turc-Carel, MD; Janusz Limon, MD; Avery A. Sandberg, MD

Arch Surg. 1987;122(11):1257-1260.

Abstract
• A cytogenetic study was performed on short-term cultures from fresh surgical specimens obtained from 41 patients with soft-tissue sarcomas of various histologic origins. The results demonstrated that myxoid liposarcomas (five tumors) were associated with a specific translocation between chromosomes 12 and 16 and that synovial sarcomas (six tumors) were associated with a specific translocation between the X chromosome and chromosome 18. These chromosomal data have been used to differentiate myxoid liposarcoma from other myxoid tumors exhibiting a noncharacteristic histologic picture, as well as to ascertain the diagnosis of synovial sarcoma in undifferentiated soft-tissue sarcomas. The results to date indicate that identification of specific chromosomal changes in sarcomas may provide a new diagnostic criterion for these tumors and possibly improve prognostication with regard to survival and response to treatment.

(Arch Surg 1987;122:1257-1260)

Author Affiliations
From the Departments of Surgical Oncology (Dr Karakousis) and Genetics and Endocrinology (Drs Dal Cin, Turc-Carel, Limon, and Sandberg), Roswell Park Memorial Institute, Buffalo.

Footnotes
Accepted for publication July 16, 1987.

Read before the Annual Meeting of the Society of Surgical Oncology, London, April 27, 1987.

Reprint requests to Department of Genetics and Endocrinology, Roswell Park Memorial Institute, 666 Elm St, Buffalo, NY 14263 (Dr Sandberg).

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