The Prognostic Significance of Natural Killer Cytotoxicity in Patients With Colorectal Cancer

doi:10.1001/archsurg.1987.01400230050009

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Vol. 122 No. 11, November 1987

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The Prognostic Significance of Natural Killer Cytotoxicity in Patients With Colorectal Cancer

Paul Ian Tartter, MD; Bryan Steinberg; Deborah M. Barron; Giorgio Martinelli, PhD

Arch Surg. 1987;122(11):1264-1268.

Abstract

• We evaluate the prognostic significance of preoperativenatural killer (NK) cytotoxicity for K562 cells and its relationshipto other prognostic factors in 102 patients with colorectalcancer who underwent curative resections between February 1984and February 1985. The 18 patients who had recurrences withintwo years of surgery had significantly higher numbers of preoperativeperipheral blood suppressor/cytotoxic and NK cells and significantlylower preoperative NK cytotoxicity than disease-free patients.Low preoperative NK cytotoxicity was predictive of recurrenceindependent of age, sex, hematocrit, procedure, blood loss,duration of surgery, Dukes' stage, specimen length, tumor size,tumor differentiation, and post-operative therapy. Low levelsof in vitro NK-cell cytotoxicity may identify a subgroup ofpatients at high risk for recurrence.

(Arch Surg 1987;122:1264-1268)

Author Affiliations

From the Department of Surgery, The Mount Sinai Medical Center, New York.

Footnotes

Accepted for publication July 16, 1987.

Read before the Annual Meeting of the Society of Surgical Oncology,London, April 30, 1987.

Reprint requests to Department of Surgery, Box 1259, Mount SinaiMedical Center, One Gustave L. Levy Place, New York, NY 10029(Dr Tartter).

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