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A Randomized Trial of Brachytherapy

Murray F. Brennan, MD; Basil Hilaris, MD; Man H. Shiu, MD; Joseph Lane, MD; Gordon Magill, MD; Claudia Friedrich; Steven I. Hajdu, MD

Arch Surg. 1987;122(11):1289-1293.

Abstract
• We conducted a prospective randomized study of the benefit of adjuvant radiation therapy delivered by the brachytherapy technique in 117 adult patients who had soft-tissue sarcoma that was on an extremity or superficially localized to the trunk. A significant decrease in local recurrence was demonstrated in the patients receiving brachytherapy. The benefit did not appear to be due to any maldistribution in the known prognostic factors of size, site, depth, presentation with recurrence, or histologic grade. The decrease in local recurrence appears to be due to the decreased local recurrence in high-grade sarcomas. Survival differences were not identified, and accrual and follow-up were continued.

(Arch Surg 1987;122:1289-1293)

Author Affiliations
From the Departments of Surgery (Drs Brennan, Shiu, and Lane and Ms Friedrich), Medicine (Dr Magill), Radiation Oncology (Dr Hilaris), and Pathology (Dr Hajdu), Memorial Sloan-Kettering Cancer Center, New York.

Footnotes
Accepted for publication July 16, 1987.

Read before the Annual Meeting of the Society of Surgical Oncology, London, April 28, 1987.

Reprint requests to Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021 (Dr Brennan).

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