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David M. Hyams, MD; Jose M. Esteban, MD; Charles P. Lollo, PhD; Barbara G. Beatty, PhD; J. David Beatty, MD

Arch Surg. 1987;122(11):1333-1337.

Abstract
• The present study was undertaken to determine whether an anti—carcinoembryonic antigen (CEA) monoclonal antibody (MAB), labeled with the potent beta emitter yttrium 90, could alter the growth of diffuse intraperitoneal carcinomatosis of colon cancer. Nude mice bearing the CEA-producing human tumor line LS174T received therapy with the anti-CEA MAB ZCE025 ⁹⁰Y. Animals were evaluated 12 days after therapy. Untreated animals had a mean (±SEM) tumor burden of 3.99±0.10 g, while animals treated with ZCE025 ⁹⁰Y had 0.29±0.04 g present. This decrease was significant compared with the 1.31 ±0.16 g of tumor present in animals treated with a ⁹⁰Y-labeled nonspecific antibody 96.5c. The therapeutic effects seen with ZCE025 ⁹⁰Y suggest a potentially useful role for ⁹⁰Y-labeled anti-CEA MABs in the treatment of gastrointestinal carcinomatosis.

(Arch Surg 1987;122:1333-1337)

Author Affiliations
From the Departments of General Oncologic Surgery (Drs Hyams, B. G. Beatty, and J. D. Beatty) and Anatomic Pathology (Dr Esteban), City of Hope National Medical Center, Duarte, Calif; and Hybritech Inc, San Diego (Dr Lollo).

Footnotes
Accepted for publication July 13, 1987.

Read before the Annual Meeting of the Society of Surgical Oncology, London, April 29, 1987.

Reprint requests to Department of General Oncologic Surgery, City of Hope National Medical Center, Duarte, CA 91010 (Dr J. D. Beatty).

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