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Dukes' Stage, Tumor Site, Preoperative Plasma CEA Level, and Patient Prognosis Related to Tumor DNA Ploidy Pattern

Nigel A. Scott, MB; Harry S. Wieand, PhD; Charles G. Moertel, MD; Stephen S. Cha, MS; Robert W. Beart, MD; Michael M. Lieber, MD

Arch Surg. 1987;122(12):1375-1379.

Abstract
• Flow cytometric DNA histograms of colorectal carcinomas from 264 patients were evaluated for the association of tumor site, Dukes' stage, tumor grade, and preoperative carcinoembryonic level with patient survival. The DNA nondiploid carcinomas were significantly more common from the left (descending and sigmoid) colon and the rectum. A poorer prognosis was found for patients with DNA nondiploid cancers than for patients with DNA diploid cancers. This was particularly true for patients with Dukes' stages B2 and C tumors with a small number (one to three) of lymph nodes with metastatic deposits. The DNA nondiploid cancers also had a relatively poorer prognosis in patients with unresectable disease. In a Cox multivariate analysis model, the DNA pattern was an independent prognostic variable for this group of 264 patients with resected colorectal carcinoma.

(Arch Surg 1987;122:1375-1379)

Author Affiliations
From the Section of Colon and Rectal Surgery (Drs Scott and Beart), and Departments of Urology (Dr Lieber), Medical Oncology (Dr Moertel and Mr Cha), and Epidemiology (Dr Wieand and Mr Cha), Mayo Clinic/Foundation, Rochester, Minn.

Footnotes
Accepted for publication July 10, 1987.

Read before the Annual Meeting of the Society of Surgical Oncology, London, April 29, 1987.

Reprint requests to Department of Urology, Mayo Clinic/Foundation, 200 First St SW, Rochester, MN 55905 (Dr Lieber).

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