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John M. Rabkin, MD; Thomas K. Hunt, MD

Arch Surg. 1987;122(2):221-225.

Abstract
• The effect of local hyperthermia on subcutaneous tissue oxygen tension (Psqo₂) and perfusion was investigated in eight patients (13 trials) using a subcutaneously implanted oxygen tonometer. Application of heat increased subcutaneous tissue temperature and Psqo₂. Mean Psqo₂ during oxygen breathing rose by 39.5 mm Hg, an 80% increase over the average baseline Psqo₂. The corresponding mean subcutaneous temperature increased 4.0°C. A significant linear correlation was found between the change in Psqo₂ and subcutaneous temperature. There was an average threefold increase in local perfusion estimated by using the Fick principle. The data reaffirm the value of local hyperthermia in treating contaminated wounds and suggest a mechanism for its ability to ameliorate infections. The mechanism implies that local heat may have prophylactic value as well.

(Arch Surg 1987;122:221-225)

Author Affiliations
From the Department of Surgery, University of California, San Francisco.

Footnotes
Accepted for publication July 17, 1986.

Read before the Sixth Annual Meeting of the Surgical Infection Society, Chicago, April 22, 1986.

Reprint requests to 839 HSE, Department of Surgery, University of California at San Francisco, San Francisco, CA 94143 (Dr Hunt).

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