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Cora K. Ogle, PhD; James D. Ogle, PhD; Carol Johnson; Linette Keynton; J. Wesley Alexander, MD, ScD

Arch Surg. 1987;122(2):234-238.

Abstract
• The effect of fluid-phase C3b on mitogen-induced lymphocyte proliferation in the presence and absence of macrophages was studied. In general, C3b inhibited the proliferation of lymphocytes when monocytes (macrophages) were present. The degree of inhibition by C3b was different for B and T lymphocytes and varied for different subpopulations of lymphocyte classes. In the absence of monocytes (macrophages), there was insignificant inhibition by C3b of lymphocyte proliferation, and thus the observed inhibition appeared to be due to the effect of C3b on the monocytes/macrophages present in the mixed lymphocyte preparations.

(Arch Surg 1987;122:234-238)

Author Affiliations
From the Departments of Surgery (Drs C. Ogle and Alexander) and Biological Chemistry (Dr J. Ogle), University of Cincinnati College of Medicine and Shriners Burns Institute (Mss Johnson and Keynton).

Footnotes
Accepted for publication Sept 17, 1986.

Read before the Sixth Annual Meeting of the Surgical Infection Society, Chicago, April 22, 1986.

Reprint requests to Department of Surgery, University of Cincinnati Medical Center, 231 Bethesda Ave, Cincinnati, OH 45267-0522 (Dr C. Ogle).

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