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Paul J. Garvin, MD; Marco Castaneda, MD; Kathleen Carney, PAC

Arch Surg. 1987;122(3):274-278.

Abstract
• Between February 1985 and April 1986, we performed 11 simultaneous cadaver kidney and segmental pancreatic transplants in patients with type I diabetes. There were nine men and two women ranging in age from 25 to 47 years (mean, 38.5 years). All pancreatic grafts were extraperitoneal, and the pancreatic duct was managed by pancreaticocystostomy utilizing an internal stent. Three patients died from two to six weeks postoperatively of septic complications. Four pancreatic grafts were functioning at 2, 5, 11, and 14 months after operation, and eight patients had had functioning renal allografts from two to 14 months (mean, 6.8 months) with a mean serum creatinine level of 2.4 mg/dL (210 µmol/L). Graft failure occurred in the other four patients from vascular thrombosis (three patients) or hemorrhagic pancreatitis (one patient). Significant morbidity included an infected arterial anastomosis (two patients), pancreatic fistulas (four patients), and bladder leak (four patients). In conclusion, this procedure is an effective option for selective diabetics with end-stage renal disease. Although technical complications were frequent, no adverse effect on renal allograft function was evident. With technical refinements, this procedure should be applicable to most type I diabetics with renal failure.

(Arch Surg 1987;122:274-278)

Author Affiliations
From the Department of Surgery, John Cochran Veterans Administration Medical Center, St Louis; and the Department of Surgery, St Louis University School of Medicine.

Footnotes
Accepted for publication Sept 19, 1986.

Read before the Tenth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Washington, DC, May 10, 1986.

Reprint requests to Department of Surgery, St Louis University Medical Center, 1325 S Grand Blvd, St Louis, MO 63104 (Dr Garvin).

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