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Correlations of Hepatic Blood Flow With Function

William J. Schirmer, MD; Michael C. Townsend, MD; James M. Schirmer; William W. Hampton, MD; Donald E. Fry, MD

Arch Surg. 1987;122(3):349-354.

Abstract
• To study hepatic blood flow with clearance techniques during sepsis, it is essential to work within the limitations of the test being applied. Based on galactose elimination kinetics, this study validates galactose clearance at low concentrations as an estimate of effective hepatic blood flow in a rat peritonitis model of cecal ligation and puncture. Hepatic function as determined by galactose elimination capacity fell 25% at ten hours after induction of peritonitis, which correlated closely with the 20% reduction in effective hepatic blood flow at the same time point despite a normal cardiac output. The pattern of reduced flow and reduced function is consistent with intrahepatic flow redistribution. Inadequate flow at the microvascular level with secondary cellular injury may explain the liver dysfunction observed during sepsis.

(Arch Surg 1987;122:349-354)

Author Affiliations
From the Department of Surgery, Case Western Reserve University Hospitals and Veterans Administration Medical Center, Cleveland. Drs Schirmer and Townsend are Dudley P. Allen Research Fellows in Surgery at Case Western Reserve University, Cleveland.

Footnotes
Accepted for publication Nov 6, 1986.

Read before the Tenth Annual Surgical Symposium of the Association of Veterans Administration Surgeons, Washington, DC, May 9, 1986.

Reprint requests to Department of Surgery, 112W, Veterans Administration Medical Center, 10701 East Blvd, Cleveland, OH 44106 (Dr Schirmer).

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