This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Howard P. Greisler, MD; Joan Ellinger; Thomas H. Schwarcz, MD; John Golan, MD; Richard M. Raymond, PhD; Dae Un Kim, MD

Arch Surg. 1987;122(6):715-721.

Abstract
• We analyzed histologic, ultrastructural, and functional characteristics of rabbit aortic conduits regenerated over absorbable polydioxanone prostheses. Twenty-eight polydioxanone-elicited prosthesis/tissue complexes harvested two weeks to 12 months following implantation were analyzed grossly; photographed; sectioned for light, scanning, and transmission electron microscopy; and studied for compliance, bursting strength, and prostacyclin and thromboxane metabolite contents. No aortic-related deaths or hemorrhages occurred. Smooth regenerated conduits without stenoses were seen in 27 of 28 specimens, with one small aneurysm. Transprosthetic myofibroblast migration and proliferation paralleled the kinetics of macrophage-mediated prosthetic dissolution, which was consequently delayed compared with polyglycolic acid prostheses. Confluent endothelial-like luminal surfaces were present after two weeks. Progressive inner capsular thickening ended after three months at 420 µm. Ex vivo compliance curves resembled arterial elasticity. Regenerated tissue withstood 1200 mm Hg of systolic pressure, and 6-keto—prostaglandin F₁ to thromboxane B₂ ratios did not differ from normal control specimens.

(Arch Surg 1987;122:715-721)

Author Affiliations
From the Department of Surgery, Loyola University Medical Center, Maywood, Ill (Drs Greisler, Schwarcz, Golan, and Raymond and Ms Ellinger), and St Barnabas Medical Center, Livingston, NJ (Dr Kim).

Footnotes
Accepted for publication Jan 16, 1986.

Reprint requests to the Department of Surgery, Loyola University Medical Center, 2160 First Ave, Maywood, IL 60153 (Dr Greisler).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Tissue engineering of autologous aorta using a new biodegradable polymer
Shum-Tim et al.
Ann. Thorac. Surg. 1999;68:2298-2304.
ABSTRACT | FULL TEXT  

Hemodynamic Effects on Endothelial Cell Monolayer Detachment From Vascular Prostheses
Greisler et al.
Arch Surg 1989;124:429-433.
ABSTRACT