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Armando Sardi, MD; John A. Singer, MD

Arch Surg. 1987;122(7):835-836.

Abstract
• The association of gastrin- and insulin-producing tumors of the pancreas is rare. In the 30 years' experience of Zollinger and others, of 40 patients with gastrinoma none had insulin-producing tumors. In contrast to patients with Zollinger-Ellison syndrome, of whom 15% to 26% are classified as having multiple endocrine neoplasias type I (MEN I), only 3% to 4% of patients with insulinomas have other endocrine neoplasms. Insulinomas in patients with MEN I are usually single tumors that usually can be cured with enucleation of the tumor. In contradistinction, gastrinomas in patients with MEN I are diffuse in nature and resection only rarely can be accomplished. Long-term management of gastric hypersection is best accomplished by H₂-receptor antagonists. If the patient does not respond to H₂-receptor antagonists or is unwilling to take the drug indefinitely, he or she will be a candidate for total gastrectomy.

(Arch Surg 1987;122:835-836)

Author Affiliations
From the Department of Surgery, St Agnes Hospital, Baltimore.

Footnotes
Accepted for publication June 3, 1986.

Reprint requests to Department of Surgery, St Agnes Hospital, 900 Caton Ave, Baltimore, MD 21229 (Dr Singer).

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