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Magruder C. Donaldson, MD; Eileen T. Matthews; Jane Hadjimichael; Frederick R. Rickles, MD

Arch Surg. 1987;122(8):897-900.

Abstract
• Levels of the platelet degranulation product β-thromboglobulin (BTG) and the fibrinogen degradation product fibrinopeptide A (FPA) were measured in 26 asymptomatic subjects (group 1), 17 patients with peripheral vascular disease (PVD) (group 2), and 12 patients with PVD and bypass grafts (group 3). Mean BTG and FPA levels were elevated in both groups 2 and 3, indicating increased thrombotic activity in patients with PVD. Results of serial BTG and FPA assays in group 3 patients suggested a trend downward. These markers may be useful for estimating disease severity and prognosis, extent of graft healing and patency, and efficacy of therapeutic intervention.

(Arch Surg 1987;122:897-900)

Author Affiliations
From the Departments of Surgery (Dr Donaldson and Ms Hadjimichael) and Hematology/Oncology (Ms Matthews and Dr Rickles), University of Connecticut School of Medicine, Farmington. Dr Donaldson is now with the Department of Surgery, Brigham and Women's Hospital, Boston.

Footnotes
Accepted for publication March 13, 1987.

Read before the 13th Annual Meeting of the New England Society for Vascular Surgery, Dixville Notch, NH, Sept 26, 1986.

Reprint requests to Department of Surgery, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (Dr Donaldson).

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