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Choledochal CystIts Possible Autonomic Involvement in the Bile Duct
Masato Kusunoki, MD;
Takehira Yamamura, MD;
Toku Takahashi, MD;
Masaru Kantoh, MD;
Yoshio Ishikawa, MD;
Joji Utsunomiya, MD
Arch Surg. 1987;122(9):997-1000.
Abstract
• The properties of the choledochal cyst were compared with those of the normal common bile duct. Cholecystokininoctapeptide and a high concentration of acetylcholine produced smaller contractions in the strips of the narrow portion of the cyst than in the strips of the dilated portion and the normal common bile duct. Nicotine did not cause contractions in the strip of the narrow portion of the cyst.  -Aminobutyric acid (GABA) induced atropine-sensitive, tetrodotoxin-sensitive contractions in the bile ducts through bicuculline-sensitive, furosemide-sensitive GABAA receptors located on the postganglionic cholinergic neuron. The GABA did not induce contractions in the narrow portion of the cyst. The number of ganglion cells was decreased markedly in the same portion. These findings suggest that the choledochal cyst has postganglionic neural dysfunction. This character may be one of the causes of cyst formation.
(Arch Surg 1987;122:997-1000)
Author Affiliations
From the Second Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan.
Footnotes
Accepted for publication Nov 5, 1986.
Reprint requests to Second Department of Surgery, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomaya 663, Japan (Dr Kusunoki).
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Choledochal Cysts: Oligoganglionosis in the Narrow Portion of the Choledochus
Kusunoki et al.
Arch Surg 1988;123:984-986.
ABSTRACT
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