 |
|
Nitrogen Balance in Adult Hospitalized Patients With the Use of a Pediatric Amino Acid Model
Alan B. Gazzaniga, MD;
Kenneth Waxman, MD;
Audrey T. Day, MA;
Ronald R. Bradford, RPh;
Jon A. Vanderhoof, MD;
Brack Bivins, MD;
Ezra Steiger, MD
Arch Surg. 1988;123(10):1275-1279.
Abstract
• Normalization of plasma amino acid patterns and that relationship to improved nitrogen balance was studied using a pediatric-specific amino acid solution in 21 adults requiring total parenteral nutrition therapy. There was a significantly positive correlation between improved nitrogen balance and the amino acids cystine, tyrosine, total cysteine/cystine, and ornithine. When additional cysteine was added to the solution of 11 subjects, taurine also correlated with nitrogen balance. Despite higher amounts of histidine in solution, plasma amino acid levels were not normalized. These amino acids, heretofore considered nonessential, may be required in specific molar ratios in stress. The use of a 30% branched-chain pediatric-balanced amino acid solution resulted in near normalization of plasma amino acid levels and group mean positive nitrogen balance.
(Arch Surg 1988;123:1275-1279)
Author Affiliations
From the Department of Surgery, University of California, Irvine (Drs Gazzaniga and Waxman and Ms Day); Medical Department, Kendall McGaw, Irvine, Calif (Mr Bradford); Departments of Pediatrics and Surgery, University of Nebraska, Omaha (Dr Vanderhoof); Division of Trauma Surgery, Henry Ford Hospital, Detroit (Dr Bivins); and the Department of Surgery, Cleveland Clinics (Dr Steiger).
Footnotes
Accepted for publication Nov 4, 1987.
Read before the Annual Scientific Meeting of the Southern California Chapter of the American College of Surgeons, Santa Barbara, Calif, Jan 16, 1987.
Reprint requests to Department of Surgery, University of California, Irvine, Irvine, CA 92717 (Dr Gazzaniga).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
|
