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Recombinant Human Tumor Necrosis Factor Increases Granulocyte Cell-Surface Complement Receptor Number
Donald Reed;
Francis D. Moore, Jr, MD
Arch Surg. 1988;123(11):1333-1336.
Abstract
• Exposure of human buffy-coat granulocytes to tumor necrosis factor (TNF) produced cellular activation as indicated by an increase in the neutrophil and monocyte cell-surface number of C3b receptors (measured by indirect immunofluorescence). The degree of receptor increase depended on the dose of TNF from 25 to 1250 pg/mL. Results of kinetic analysis confirmed this response: TNF, 250 pg/mL, caused an increase in the C3b receptor number within ten minutes. Purified neutrophils exhibited a similar increase in cell-surface C3b receptors dependent on the concentration of TNF. Tumor necrosis factor could be a mediator of granulocyte activation in patients.
(Arch Surg 1988;123:1333-1336)
Author Affiliations
From the Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston.
Footnotes
Accepted for publication June 20, 1988.
Read before the Eighth Annual Meeting of the Surgical Infection Society, San Francisco, May 6, 1988.
Reprint requests to Department of Surgery, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115 (Dr Moore).
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