You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 123 No. 11, November 1988 TABLE OF CONTENTS
  Archives
  •  Online Features
  PAPERS READ BEFORE THE EIGHTH ANNUAL MEETING OF THE SURGICAL INFECTION SOCIETY, SAN FRANCISCO, MAY 5 TO MAY 6, 1988
 This Article
 •References
 •Full text PDF
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit Add to Technorati Add to Twitter What's this?

Cachectin/TNF Production in Experimental Burns and Pseudomonas Infection

Michael A. Marano, MD; Lyle L. Moldawer, PhD; Yuman Fong, MD; He Wei, MD; Joseph Minei, MD; Roger Yurt, MD; Anthony Cerami, PhD; Stephen F. Lowry, MD

Arch Surg. 1988;123(11):1383-1388.


Abstract

• Burn injury and infection result in significant losses of lean tissue. The cytokine cachectin/tumor necrosis factor has been implicated in this process but is not uniformly detected during infection. We sought to determine the relationship between body composition changes and in vivo hepatic levels of pretranslational message for cachectin (messenger RNA) in a burn and infection rodent model. Adult Wistar rats were grouped as follows: (1) freely fed, (2) 30% burn, (3) 30% burn with Pseudomonas aeruginosa infection, (4) pair fed, and (5) 30% burn and infection with recombinant cachectin. Compared with controls or animals only burned, burned and infected rats had a 100% increase in hepatic cachectin messenger RNA content, lost carcass protein, and exhibited muscle loss with sparing of liver mass. Tissue production of cachectin as well as other cytokines may be sufficient to mediate several body composition changes observed in response to injury and infection.

(Arch Surg 1988;123:1383-1388)



Author Affiliations

From the Laboratory of Surgical Metabolism (Drs Marano, Moldawer, Fong, Wei, and Lowry) and the Department of Surgery (Drs Marano, Moldawer, Fong, Wei, Minei, Yurt, and Lowry), The New York Hospital—Cornell Medical Center; and the Laboratory of Medical Biochemistry, The Rockefeller University, New York (Dr Cerami).


Footnotes

Accepted for publication July 19, 1988.

Read before the Eighth Annual Meeting of the Surgical Infection Society, San Francisco, May 5, 1988.

Reprint requests to The New York Hospital, 525 E 68th St, F-2016, New York, NY 10021 (Dr Lowry).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Systemic and Liver Cytokine Activation: Implications for Liver Regeneration and Posthepatectomy Endotoxemia and Sepsis
Enayati et al.
Arch Surg 1994;129:1159-1164.
ABSTRACT  

Additive Effects of Thermal Injury and Infection on Gut Permeability
Ryan et al.
Arch Surg 1994;129:325-328.
ABSTRACT  

Skeletal Muscle Amino Acid and Myofibrillar Protein mRNA Response to Thermal Injury and Infection Y. FONG, J. P. MINEI, M. A. MARANO, ET AL American Journal of Physiology 261:R536--R542, 1991
Ziegler
JPEN J Parenter Enteral Nutr 1992;16:183-185.
ABSTRACT  

Sepsis, Signals, and Surgical Sequelae (A Hypothesis)
Michie and Wilmore
Arch Surg 1990;125:531-536.
ABSTRACT  

Identification of a Novel Tumor Necrosis Factor {alpha}Cachectin From the Livers of Burned and Infected Rats
Keogh et al.
Arch Surg 1990;125:79-85.
ABSTRACT  

The Wound Is a Possible Source of Posttraumatic Immunosuppression
Lazarou et al.
Arch Surg 1989;124:1429-1431.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1988 American Medical Association. All Rights Reserved.