This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Jane Shelby; Garrett Hisatake

Arch Surg. 1988;123(11):1397-1399.

Abstract
• Transfusion-induced immunosuppression has been associated with excessive production of prostaglandin E and decreased interleukin 2 (IL-2) production. In the present study, allogeneic blood—transfused mice were tested for cell-mediated immunity with the use of a delayed-type hypersensitivity assay. In vivo administration of a cyclo-oxygenase inhibitor, ibuprofen, and murine recombinant IL-2 was initiated on day 0 and continued daily throughout the delayed-type hypersensitivity assay. The results indicate that prostaglandin E may play a primary role in allogeneic blood transfusion—induced suppression, as manifest by normal responses in ibuprofentreated mice. Supplementation of transfused mice with recombinant IL-2 also preserved immune response, indicating inadequate IL-2 production after transfusion, while receptor expression appears to remain intact.

(Arch Surg 1988;123:1397-1399)

Author Affiliations
From the Department of Surgery, University of Utah Medical Center, Salt Lake City.

Footnotes
Accepted for publication June 16, 1988.

Read before the Eighth Annual Meeting of the Surgical Infection Society, San Francisco, May 6, 1988.

Reprint requests to Department of Surgery, University of Utah Medical Center, 50 N Medical Dr, Salt Lake City, UT 84132 (Ms Shelby).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?