This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Michael S. Dahn, MD; M. Patricia Lange, MSN; Lloyd A. Jacobs, MD

Arch Surg. 1988;123(11):1409-1414.

Abstract
• We studied the response of 14 normal volunteers and five septic patients to a 48-hour course of exogenous biosynthetic human growth hormone (hGH) or placebo. Six normal controls (group 1) received saline, eight normal controls received hGH (group 2), and five septic patients also received biosynthetic hGH (group 3). Urinary urea excretion declined, and splanchnic amino acid uptake was maintained only in group 2 subjects. Septic patients exhibited changes in amino acid and urea dynamics comparable to those of subjects receiving placebo. Insulinlike growth factor 1 (IGF-1) production and plasma concentrations increased in group 2 in a fashion corresponding to the changes in nitrogen exchange, whereas septic patients exhibited no change in IGF-1 level. Therefore, in this septic patient group, exogenous hGH was ineffective in attenuating nitrogen losses and stimulating IGF-1 production. This supports the hypothesis that IGF-1 is a mediator of the anabolic effect of hGH.

(Arch Surg 1988;123:1409-1414)

Author Affiliations
From the Surgical Service, Veterans Administration Medical Center, Allen Park, Mich; and the Department of Surgery, Wayne State University, Detroit.

Footnotes
Accepted for publication July 20, 1988.

Read before the Eighth Annual Meeting of the Surgical Infection Society, San Francisco, May 6, 1988.

Reprint requests to University Health Center, 6-C, 4201 St Antoine, Detroit, MI 48201 (Dr Dahn).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Nuclear Factor-{kappa}B Mediates the Inhibitory Effects of Tumor Necrosis Factor-{alpha} on Growth Hormone-Inducible Gene Expression in Liver
Buzzelli et al.
Endocrinology 2008;149:6378-6388.
ABSTRACT | FULL TEXT  

Acute Oral Leucine Administration Stimulates Protein Synthesis during Chronic Sepsis through Enhanced Association of Eukaryotic Initiation Factor 4G with Eukaryotic Initiation Factor 4E in Rats
Vary
J. Nutr. 2007;137:2074-2079.
ABSTRACT | FULL TEXT  

Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytes
Ahmed et al.
Am. J. Physiol. Gastrointest. Liver Physiol. 2007;292:G1793-G1803.
ABSTRACT | FULL TEXT  

Tumor necrosis factor inhibits growth hormone-mediated gene expression in hepatocytes
Ahmed et al.
Am. J. Physiol. Gastrointest. Liver Physiol. 2006;291:G35-G44.
ABSTRACT | FULL TEXT  

Inactivation of Kupffer cells by gadolinium administration prevents lipopolysaccharide-induced decrease in liver insulin-like growth factor-I and IGF-binding protein-3 gene expression.
Granado et al.
J Endocrinol 2006;188:503-511.
ABSTRACT | FULL TEXT  

Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytes
Shumate et al.
Am. J. Physiol. Gastrointest. Liver Physiol. 2005;289:G227-G239.
ABSTRACT | FULL TEXT  

Insulin-like growth factor 1 improves the relationship between systemic oxygen consumption and delivery in piglets after cardiopulmonary bypass
Li et al.
J. Thorac. Cardiovasc. Surg. 2004;127:1436-1441.
ABSTRACT | FULL TEXT  

Postreceptor Resistance to Exogenous Growth Hormone Exists in the Jejunal Mucosa of Parenterally Fed Rats
Dahly et al.
J. Nutr. 2004;134:530-537.
ABSTRACT | FULL TEXT  

Endocrine and Metabolic Effects of Growth Hormone (GH) Compared with GH-Releasing Peptide, Thyrotropin-Releasing Hormone, and Insulin Infusion in a Rabbit Model of Prolonged Critical Illness
Weekers et al.
Endocrinology 2004;145:205-213.
ABSTRACT | FULL TEXT  

NO plays a role in LPS-induced decreases in circulating IGF-I and IGFBP-3 and their gene expression in the liver
Priego et al.
Am. J. Physiol. Endocrinol. Metab. 2004;286:E50-E56.
ABSTRACT | FULL TEXT  

Combined growth hormone/insulin-like growth factor I in addition to glutamine-supplemented TPN results in net protein anabolism in critical illness
Carroll et al.
Am. J. Physiol. Endocrinol. Metab. 2004;286:E151-E157.
ABSTRACT | FULL TEXT  

Alteration of somatotropic function by proinflammatory cytokines
Frost and Lang
J ANIM SCI 2004;82:E100-109.
ABSTRACT | FULL TEXT  

Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation
Hong-Brown et al.
Am. J. Physiol. Endocrinol. Metab. 2003;285:E63-E72.
ABSTRACT | FULL TEXT  

Tumor necrosis factor mediates hepatic growth hormone resistance during sepsis
Yumet et al.
Am. J. Physiol. Endocrinol. Metab. 2002;283:E472-E481.
ABSTRACT | FULL TEXT  

Acute Stress Response in Children with Meningococcal Sepsis: Important Differences in the Growth Hormone/Insulin-Like Growth Factor I Axis between Nonsurvivors and Survivors
de Groof et al.
J. Clin. Endocrinol. Metab. 2002;87:3118-3124.
ABSTRACT | FULL TEXT  

Guest Editorial: What Do the Serum Proteins Tell Us About Our Elderly Patients?
Sullivan
Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2001;56:71M-74.
FULL TEXT  

Interleukin-6 Stimulates Hepatic Insulin-Like Growth Factor Binding Protein-4 Messenger Ribonucleic Acid and Protein
Fernandez-Celemin and Thissen
Endocrinology 2001;142:241-248.
ABSTRACT | FULL TEXT  

IGF-I/IGFBP-3 binary complex modulates sepsis-induced inhibition of protein synthesis in skeletal muscle
Svanberg et al.
Am. J. Physiol. Endocrinol. Metab. 2000;279:E1145-E1158.
ABSTRACT | FULL TEXT  

Potentiation of Growth Hormone-Induced Liver Suppressors of Cytokine Signaling Messenger Ribonucleic Acid by Cytokines
Colson et al.
Endocrinology 2000;141:3687-3695.
ABSTRACT | FULL TEXT  

ACUTE EFFECTS OF GROWTH HORMONE IN ALCOHOL-FED RATS
Lang et al.
Alcohol Alcohol 2000;35:148-158.
ABSTRACT | FULL TEXT  

Role of the Suppressor of Cytokine Signaling-3 in Mediating the Inhibitory Effects of Interleukin-1beta on the Growth Hormone-dependent Transcription of the Acid-labile Subunit Gene in Liver Cells
Boisclair et al.
J. Biol. Chem. 2000;275:3841-3847.
ABSTRACT | FULL TEXT  

Endotoxin-Induced Inhibition of Growth Hormone Receptor Signaling in Rat Liver in Vivo
Mao et al.
Endocrinology 1999;140:5505-5515.
ABSTRACT | FULL TEXT  

Effects of Insulin-Like Growth Factor-I and Growth Hormone in Models of Parenteral Nutrition
Ney
JPEN J Parenter Enteral Nutr 1999;23:S184-S189.
ABSTRACT  

Insulin-like growth factor I response during nutritional rehabilitation of persistent diarrhoea
Bhutta et al.
Arch. Dis. Child. 1999;80:438-442.
ABSTRACT | FULL TEXT  

GH insensitivity induced by endotoxin injection is associated with decreased liver GH receptors
Defalque et al.
Am. J. Physiol. Endocrinol. Metab. 1999;276:E565-E572.
ABSTRACT | FULL TEXT  

The Acid-Labile Subunit of Human Ternary Insulin-Like Growth Factor Binding Protein Complex in Serum: Hepatosplanchnic Release, Diurnal Variation, Circulating Concentrations in Healthy Subjects, and Diagnostic Use in Patients with Growth Hormone Deficiency
Juul et al.
J. Clin. Endocrinol. Metab. 1998;83:4408-4415.
ABSTRACT | FULL TEXT  

Differential regulation of skeletal muscle protein turnover by insulin and IGF-I after bacteremia
Vary et al.
Am. J. Physiol. Endocrinol. Metab. 1998;275:E584-E593.
ABSTRACT | FULL TEXT  

Treatment of burned rats with insulin-like growth factor I inhibits the catabolic response in skeletal muscle
Fang et al.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 1998;275:R1091-R1098.
ABSTRACT | FULL TEXT  

Effects of Intensive Chemotherapy on Bone and Collagen Turnover and the Growth Hormone Axis in Children with Acute Lymphoblastic Leukemia
Crofton et al.
J. Clin. Endocrinol. Metab. 1998;83:3121-3129.
ABSTRACT | FULL TEXT  

Metabolic Effects of Adjuvant Recombinant Human Growth Hormone in Patients With Continuing Sepsis Receiving Parenteral Nutrition
Bettany et al.
JPEN J Parenter Enteral Nutr 1998;22:199-205.
ABSTRACT  

Effects of Insulin-Like Growth Factor 1 on Neutrophil and Monocyte Functions in Normal and Septic States
Balteskard et al.
JPEN J Parenter Enteral Nutr 1998;22:127-135.
ABSTRACT  

Inhibition by Interleukin-1{beta} and Tumor Necrosis Factor-{alpha} of the Insulin-Like Growth Factor I Messenger Ribonucleic Acid Response to Growth Hormone in Rat Hepatocyte Primary Culture
Thissen and Verniers
Endocrinology 1997;138:1078-1084.
ABSTRACT | FULL TEXT  

1995 Jonathan E. Rhoads Lecture. The Nutrition Management of the Patient With Acute Renal Failure
Kopple
JPEN J Parenter Enteral Nutr 1996;20:3-12.
ABSTRACT  

Insulin-like Growth Factor-I Prevents Gut Atrophy and Maintains Intestinal Integrity in Septic Rats
Chen et al.
JPEN J Parenter Enteral Nutr 1995;19:119-124.
ABSTRACT  

Invited Review: Nutrition Support in Critical Illness
Barton
Nutr Clin Pract 1994;9:127-139.
ABSTRACT  

Impact of Exogenous Insulinlike Growth Factor 1 on Hepatic Energy Metabolism in Burn Injury
Dong et al.
Arch Surg 1993;128:703-708.
ABSTRACT  

Insulinlike Growth Factor 1 (IGF-1) Reduces Gut Atrophy and Bacterial Translocation After Severe Burn Injury
Huang et al.
Arch Surg 1993;128:47-54.
ABSTRACT  

The Horror Autotoxicus and Multiple-Organ Failure
Baue
Arch Surg 1992;127:1451-1462.
ABSTRACT  

Growth Hormone and Nutritional Support: Adverse Metabolic Effects
Lehmann and Cerra
Nutr Clin Pract 1992;7:27-30.
ABSTRACT  

Nutritional Support: Service in Need of New Science
Rombeau
JPEN J Parenter Enteral Nutr 1989;13:445-449.