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Hideko Arita, MD; Cora K. Ogle, PhD; J. Wesley Alexander, MD, ScD; Glenn D. Warden, MD

Arch Surg. 1988;123(11):1420-1424.

Abstract
• Endotoxin has been suspected of inducing hypermetabolism in animals. To delineate its mechanism more precisely, three experiments were performed using male Hartley guinea pigs that involved intermittent or continuous adminstration of endotoxin intraperitoneally for seven days and continuous infusion of low-dose endotoxin through the portal vein for five days. The doses of endotoxin were 0.3 mg, 0.36 mg, and 0.014 mg per 100 g of body weight per day, respectively. Hypermetabolic response was induced only in the experiment involving the infusion of endotoxin through the portal vein; the hypermetabolic response was correlated significantly with endotoxin levels in the plasma. These results indicate that endotoxin translocated from the gut into the mesenteric vein will induce hypermetabolism more readily than endotoxin translocated into the peritoneal cavity.

(Arch Surg 1988;123:1420-1424)

Author Affiliations
From the Shriners Burn Institute, Cincinnati Unit. Dr Arita is now with the University of Tokyo.

Footnotes
Accepted for publication June 16, 1988.

Read before the Eighth Annual Meeting of the Surgical Infection Society, San Francisco, May 6, 1988.

Reprint requests to Shriners Burn Institute, 202 Goodman St, Cincinnati, OH 45219 (Dr Ogle).

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