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A Comparison of the Penetration of Two Quinolones Into Intra-abdominal Abscess
Richard G. Tudor, BSc, MD, FRCS;
Denise J. Youngs;
Kazihuto Yoshioka, MD;
Douglas W. Burdon, MD, MRCPATH;
Michael R. B. Keighley, MS, FRCS
Arch Surg. 1988;123(12):1487-1490.
Abstract
• A low-mortality model of an intra-abdominal abscess in the rat has been used to study the penetration of two quinolone agents into pus. Maximum concentrations in pus after intravenous injections were achieved at four hours (ciprofloxacin: 12.7±3.69 mg/L, fleroxacin: 2.25±1.82 mg/L), whereas fleroxacin given orally reached the maximum level at two hours (13.39±3.13 mg/L). Higher concentrations of fleroxacin were recorded in pus than in serum at each time point up to eight hours after administration, but pus levels of ciprofloxacin only exceeded serum levels after 1.5 hours. These antibiotics appear to have a unique property of high penetration into established abscesses and may have an important therapeutic role in the treatment of patients with multiple interloop abscesses.
(Arch Surg 1988;123:1487-1490)
Author Affiliations
From the Departments of Surgery (Drs Tudor, Yoshioka, and Keighley) and Microbiology (Ms Youngs and Dr Burdon), The General Hospital, Birmingham, United Kingdom.
Footnotes
Accepted for publication June 16, 1988.
Read before the Eighth Annual Meeting of the Surgical Infection Society, San Francisco, May 6, 1988.
Reprint requests to Clinical Teaching Block, The General Hospital, Steelhouse Lane, Birmingham B4 6NH, United Kingdom (Dr Keighley).
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