This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (102)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

An Autopsy Study

Hans K. S. Nuytinck, MD, PhD; Xavier J. M. W. Offermans, MD; Karel Kubat, MD, PhD; R. Jan A. Goris, MD, PhD

Arch Surg. 1988;123(12):1519-1524.

Abstract
• In a review of autopsy specimens and reports in 35 trauma cases, we found signs of generalized inflammation and tissue damage with increases in organ weights in organs not primarily injured. These abnormalities occurred independent of the time of death and were also found in patients who died of brain injury alone. The most pronounced signs of inflammation and increases in organ weights were found when the adult respiratory distress syndrome, hypovolemic shock, or multiple organ failure were the causes of death. These findings are similar to those found in several organs of rabbits after four hours of complement activation in combination with 20 minutes of hypoxia. Therefore, the autopsy findings in this series of trauma patients might represent the morphologic features of adult respiratory distress syndrome and multiple organ failure in an early, preclinical stage.

(Arch Surg 1988;123:1519-1524)

Author Affiliations
From the Departments of General Surgery (Drs Nuytinck, Offermans, and Goris) and Pathology (Dr Kubat), University Hospital St Radboud, Nijmegen, the Netherlands. Dr Nuytinck is now with St Ignatius Hospital, Breda, the Netherlands.

Footnotes
Accepted for publication Sept 29, 1987.

Read in part at the First Vienna Shock Forum, Vienna, May 1, 1986.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A systematic review of antibiotic dosing regimens for septic patients receiving continuous renal replacement therapy: do current studies supply sufficient data?
Li et al.
J Antimicrob Chemother 2009;64:929-937.
ABSTRACT | FULL TEXT  

Reamed Femoral Nailing in Sheep: Does Irrigation and Aspiration of Intramedullary Contents Alter the Systemic Response?
Pape et al.
JBJS 2005;87:2515-2522.
ABSTRACT | FULL TEXT  

A 12-Year Prospective Study of Postinjury Multiple Organ Failure: Has Anything Changed?
Ciesla et al.
Arch Surg 2005;140:432-440.
ABSTRACT | FULL TEXT  

Prevention of post-traumatic clinical capillary leak syndrome
Gosling
Trauma 1999;1:91-103.
ABSTRACT  

Mechanisms of acute inflammatory lung injury induced by abdominal sepsis
Neumann et al.
Int Immunol 1999;11:217-227.
ABSTRACT | FULL TEXT  

Development of a Bacteria-Independent Model of the Multiple Organ Failure Syndrome
Steinberg et al.
Arch Surg 1989;124:1390-1395.
ABSTRACT