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The Relationship Between fMet-Leu-Phe Receptor Mobilization and Oxidative Activity

Steven D. Tennenberg, MD; Joseph S. Solomkin, MD

Arch Surg. 1988;123(2):171-175.

Abstract
• To elucidate further the manifestations and mechanisms of neutrophil (PMN) activation, PMNs from control and septic subjects were studied at baseline and under conditions of graded, in vitro activation. At baseline (4°C PMN isolation), septic-derived PMNs were activated, as manifested by twofold increases in fmet-leu-phe (FMLP)-induced oxidative activity and concomitant FMLP surface receptor expression, compared with controls. Following degranulationlike maximal activation (phorbol myristate acetate pretreatment), both PMN populations exhibited maximal FMLP-induced oxidative priming and receptor up-regulation. However, following exudationlike moderate activation (37°C pretreatment), control PMNs underwent significant receptor mobilization and oxidative priming but septic-derived PMNs exhibited oxidative deactivation (decreased FMLP-induced oxidative activity) without changes in FMLP receptor expression. Our data support the theory that while circulating PMNs in sepsis may promote oxidant-related microvascular lung injury, their oxidative deactivation following transpulmonary exudation (simulated by 37°C pretreatment) may underlie the increased incidence of pulmonary infections seen in sepsis-induced adult respiratory distress syndrome.

(Arch Surg 1988;123:171-175)

Author Affiliations
From the Department of Surgery, University of Cincinnati College of Medicine.

Footnotes
Accepted for publication Aug 24, 1987.

Read before the Seventh Annual Meeting of the Surgical Infection Society, Philadelphia, May 11, 1987.

Reprint requests to Department of Surgery, University of Cincinnati College of Medicine, 231 Bethesda Ave, Cincinnati, OH 45267-0558 (Dr Tennenberg).

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