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Mats Heideman, MD, PhD; Birgitta Norder-Hansson; Anders Bengtson, MD, PhD; Tom Eirik Mollnes, MD, PhD

Arch Surg. 1988;123(2):188-192.

Abstract
• Terminal complement complex (TCC) and anaphylatoxin formation in 18 patients with sepsis and 20 patients with acute limb ischemia were studied before the start of treatment and seven days later. The septic or ischemic patients had elevated levels of plasma TCC before start of therapy. In successfully treated patients these concentrations were within the normal range one week later. Similarly, the plasma anaphylatoxin level was increased before therapy and returned to the normal range within seven days. Escherichia coli incubated in vitro in fresh human serum at body temperature started formation of TCC in a dose-related manner. As complement will induce cellular lysis via TCC and edema via anaphylatoxins, anemia and impaired respiration in these patients may be influenced by increased concentrations of terminal complement complexes and of C3a and C5a.

(Arch Surg 1988;123:188-192)

Author Affiliations
From the Department of Surgery I (Dr Heideman and Ms Norder-Hansson) and the Department of Anesthesiology and Intensive Care (Dr Bengtson), Sahlgren's Hospital, Gothenburg, Sweden; and the Institute of Immunology and Rheumatology, Rikshospitalet, Oslo (Dr Mollnes).

Footnotes
Accepted for publication Sept 22, 1987.

Read before the Seventh Annual Meeting of the Surgical Infection Society, Philadelphia, May 11, 1987.

Reprint requests to Department of Surgery I, Sahlgren's Hospital, S-413 45 Gothenburg, Sweden (Dr Heideman).

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